Alpha event‐related synchronization after eye closing differs in Alzheimer’s disease and dementia with Lewy bodies: a magnetoencephalography study
Alpha event‐related synchronization after eye closing differs in Alzheimer’s disease and dementia with Lewy bodies: a magnetoencephalography study
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闭眼后阿尔法事件相关同步在阿尔茨海默病和路易体痴呆中存在差异：一项脑磁图研究
DOI：
10.1111/psyg.12313
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发表时间：
2018
期刊：
影响因子：
2
通讯作者：
Masahiro Hata Ryu Kurimoto Hiroaki Kazui Ryouhei Ishii Leonides Canuet Yasunori Aoki Shunichiro Ikeda Shingo Azuma Takashi Suehiro Shunsuke Sato Yukiko Suzuki Hideki Kanemoto Kenji Yoshiyama Masao Iwase Manabu Ikeda
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文献类型：
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作者：
Ishii Ryouhei;Canuet Leonides;Masahiro Hata Ryu Kurimoto Hiroaki Kazui Ryouhei Ishii Leonides Canuet Yasunori Aoki Shunichiro Ikeda Shingo Azuma Takashi Suehiro Shunsuke Sato Yukiko Suzuki Hideki Kanemoto Kenji Yoshiyama Masao Iwase Manabu Ikeda
路易体痴呆患者的脑电(EEG)异常是相互矛盾的。在这项研究中，我们使用比脑电具有更高空间分辨率的脑磁图来探索可能有助于DLB鉴别诊断的神经生理学特征。方法6例DLB患者，11例阿尔茨海默病患者和11例年龄匹配的正常人。结果虽然所有研究组闭眼后α频段事件相关同步(ERS)的平均比率变化主要集中在后脑区，但DLB患者的αERS比率变化最小。与阿尔茨海默病患者和正常对照组相比，DLB患者双侧颞下回、右侧枕极和左侧顶枕皮质的αERS比值变化明显降低。结论闭眼引起的后脑区αERS比值变化是DLB的一种脑电磁特征。
BackgroundThe electroencephalography (EEG) abnormalities found in patients with dementia with Lewy bodies (DLB) are conflicting. In this study, we used magnetoencephalography, which has higher spatial resolution than electroencephalography, to explore neurophysiological features of DLB that may aid in the differential diagnosis.MethodsSix patients with DLB, 11 patients with Alzheimer's disease, and 11 age‐matched normal subjects were recruited. We investigated alterations in the ratio of event‐related synchronization (ERS) in the alpha band after eye‐closing.ResultsAlthough the averaged ratio change of alpha ERS after eye‐closing appeared predominantly in the posterior brain regions in all study groups, DLB patients had the weakest ratio change of alpha ERS. In particular, DLB patients exhibited a significantly reduced ratio change of alpha ERS in the bilateral inferior temporal gyrus, right occipital pole, and left parieto‐occipital cortex compared to Alzheimer's disease patients or normal controls.ConclusionOur findings indicated that a reduced ratio change of alpha ERS in the posterior brain regions elicited by eye‐closing is a brain electromagnetic feature of DLB.