Pathologic delineation of the papillonodular type of cystic partially differentiated nephroblastoma. A review of 11 cases
Pathologic delineation of the papillonodular type of cystic partially differentiated nephroblastoma. A review of 11 cases
复制标题
囊性部分分化肾母细胞瘤乳头结节型的病理学描绘。
作者：
V. Joshi;J. Beckwith
本文报告11例先前未被识别的囊性部分分化肾母细胞瘤（CPDN）的乳头状瘤变。这种类型的CPDN具有常规类型的CPDN的所有特征；然而，除此之外，有明显的乳头状结节状突起，从间隔延伸到囊肿腔内。间隔未见任何扩张性肿瘤肿块。与大多数传统类型的病例一样，这种新型CPDN通常在婴儿中被诊断出来。这些病例均行肾切除术（全部10例，部分1例）。有7例患者接受了放疗或不放疗的化疗。有随访资料的8例患者在21个月至8年的时间内未见复发。对于可能复发的肾切除术和定期随访可能是治疗的选择。病理学家应注意CPDN的这种变异，以避免过度治疗。修订后的CPDN诊断标准可总结如下：(1)离散的全囊性肿瘤在某些情况下含有腔内乳头状结节。(2)间隔和乳头小瘤是肿瘤的唯一实体部分，包含胚细胞及其正常和异常衍生物的混合。(3)无乳头状结节和有乳头状结节的肿瘤分别分为常规型和乳头状结节型CPDN。
Eleven cases of a previously unrecognized papillonodular variant of cystic partially differentiated nephroblastoma (CPDN) are described. This type of CPDN has all the features of the conventional type of CPDN; however, in addition, there are grossly demonstrable papillonodular projections extending from the septa into the cyst lumina. The septa do not show any expansile tumor masses. Like most cases of the conventional type, this new type of CPDN was usually diagnosed in infants. Nephrectomy (total in 10 and partial in 1) was done in these cases. Additional chemotherapy with or without radiation therapy was given in seven cases. No recurrence was noted during the period extending from 21 months to 8 years in the eight cases in which follow‐up data are available. Nephrectomy with regular follow‐up visits for possible recurrence may be the management of choice. Pathologists should be aware of this variant of CPDN so that overtreatment can be avoided. The revised criteria for CPDN can be summarized as follows: (1) The discrete entirely cystic tumor contains luminal papillonodules in some cases. (2) Septa and the papillonodules, when present, are the only solid portion of the tumor and contain blastemal cells admixed with their normal and aberrant derivatives. (3) The tumor without and with papillonodules is classified as a conventional and papillonodular type of CPDN, respectively.
儿童肾肿瘤的超微结构和组织发生：概述。
影响因子：
1
作者：
Mierau,GW;Beckwith,JB;Weeks,DA
通讯作者：
Weeks,DA