Phase precession and variable spatial scaling in a periodic attractor map model of medial entorhinal grid cells with realistic after-spike dynamics
Phase precession and variable spatial scaling in a periodic attractor map model of medial entorhinal grid cells with realistic after-spike dynamics
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DOI：
10.1002/hipo.20939
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发表时间：
2012-04-01
期刊：
影响因子：
3.5
通讯作者：
McNaughton, Bruce L.
中科院分区：
文献类型：
--
作者：
Navratilova, Zaneta;Giocomo, Lisa M.;McNaughton, Bruce L.
我们提出了一个模型，描述了生成的空间（网格字段）和时间（相位进动）属性的内侧内嗅皮层（MEC）神经元相结合的网络和内在的细胞特性。该模型结合了来自早期吸引子映射模型的网络架构，并实现了1D的简单。以与大鼠速度成比例的强度以θ频率周期性地驱动合取（位置X头部方向）第III层MEC细胞，以相应的速度在网络空间中向前移动活动凸块。除了延长的兴奋性电流和简单的后尖峰动力学类似的MEC星状细胞中观察到的（新的数据）占相位进动和网格字段的规模变化沿着MEC的背腹轴。模型中的相位进动取决于突触连接和内在电流，其中每一个都在进入或退出网格场期间驱动神经尖峰。因此，该模型预测相位进动的斜率在进入和退出场之间变化。该模型还表现出独立的变化，在网格的空间周期和网格场的大小，这表明可能的实验测试的模型。(c)2011 Wiley Periodicals，Inc.
We present a model that describes the generation of the spatial (grid fields) and temporal (phase precession) properties of medial entorhinal cortical (MEC) neurons by combining network and intrinsic cellular properties. The model incorporates network architecture derived from earlier attractor map models, and is implemented in 1D for simplicity. Periodic driving of conjunctive (position x head-direction) layer-III MEC cells at theta frequency with intensity proportional to the rat's speed, moves an activity bump forward in network space at a corresponding speed. The addition of prolonged excitatory currents and simple after-spike dynamics resembling those observed in MEC stellate cells (for which new data are presented) accounts for both phase precession and the change in scale of grid fields along the dorso-ventral axis of MEC. Phase precession in the model depends on both synaptic connectivity and intrinsic currents, each of which drive neural spiking either during entry into, or during exit out of a grid field. Thus, the model predicts that the slope of phase precession changes between entry into and exit out of the field. The model also exhibits independent variation in grid spatial period and grid field size, which suggests possible experimental tests of the model. (c) 2011 Wiley Periodicals, Inc.