Drug use in first pregnancy and lactation: a population-based survey among Danish women
Drug use in first pregnancy and lactation: a population-based survey among Danish women
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DOI：
10.1007/s002280050608
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发表时间：
1999-04-01
影响因子：
2.9
通讯作者：
Sorensen, HT
中科院分区：
文献类型：
--
作者：
Olesen, C;Steffensen, FH;Sorensen, HT
目的：了解丹麦妇女从孕前12周至产后12周的用药情况。方法：以北日德兰处方数据库为基础进行药物利用研究。丹麦药房对所有补贴药品使用计算机会计系统，该系统与丹麦医疗出生登记处有关1991年至1996年在北日德兰县分娩的所有妇女的处方模式相联系。该分析包括16001名初产妇，她们在怀孕前、怀孕期间和怀孕后使用了34834张处方。44.2%的妇女在怀孕期间获得至少一种药物的处方，使用者在怀孕期间平均获得2.6个处方；5%的用户赎回了24.2%的处方。购买三种以上不同药物的女性比例为2.7%。处方以抗生素（28.7%）、妇科药物（13.3%）和抗哮喘药物（7.6%）为主。产后处方比例为34.0%，其中以青霉素类（20.1%）、眼科类（15.5%）和皮肤用皮质类固醇（5.7%）为主。结论：妊娠期用药比例较高。解剖治疗化学（ATC）组的用药格局发生变化，即广谱抗生素用量减少，局部用药比例增加。一小部分妇女在怀孕期间使用了三种以上不同的药物。
Objective: To examine the drug prescription pattern in Danish women from 12 weeks prior to conception until 12 weeks post-partum.Method: A drug utilization study based on The North Jutland Prescription Database. The Danish pharmacies use a computerized accounting system for all subsidized drugs and this was linked to the Danish Medical Birth Registry concerning prescription patterns for all women who had given birth in the county of North Jutland from 1991 to 1996.Results. The analysis included 16 001 primiparous women, who had redeemed 34 834 prescriptions prior to, during and after pregnancy. During pregnancy 44.2% of the women received prescriptions for at least one drug, Users received 2.6 prescriptions on average during pregnancy; 5% of the users redeemed 24.2% of all prescriptions. The proportion of women who redeemed prescriptions for more than three different drugs was 2.7%. The majority of prescriptions were for antibiotics (28.7%), gynaecological drugs (13.3%) and anti-asthma drugs (7.6%). The post-partum prescription proportion was 34.0% and the majority of the prescriptions during this period were for penicillins (20.1%), opthalmologicals (15.5%) and corticosteroids for dermatological use (5.7%).Conclusion: A high proportion of the women received drugs during pregnancy. The pattern of drug use within the Anatomical Therapeutical Chemical (ATC) groups changed, i.e. the amount of broad spectrum antibiotics decreased and the proportion of prescriptions for local use increased. A small proportion of women redeemed prescriptions for more than three different drugs during pregnancy.