Reduction in the Developmental Potential of Intrathymic T Cell Progenitors with Age1
Reduction in the Developmental Potential of Intrathymic T Cell Progenitors with Age1
复制标题
胸腺内 T 细胞祖细胞的发育潜力随 Age1 降低
作者：
Hyeyoung Min;E. Montecino;K. Dorshkind
目前的胸腺退化模型表明，胸腺内 T 细胞前体的内在发育缺陷不会导致与年龄相关的胸腺生成功能下降。根据最近对早期 T 谱系祖细胞 (ETP) 的定义，在小鼠模型中重新评估了这一前提，该祖细胞似乎是迄今为止定义的最早的胸腺内前体。结果表明，ETP 的频率随着年龄的增长而下降，并且它们重建胸腺的潜力也随之减弱。这些发现与以下事实相一致：与年轻动物相比，老年小鼠的 ETP 增殖较少，细胞凋亡率较高。总而言之，这些数据表明，在尝试恢复退化胸腺活力时，应考虑 T 细胞前体的年龄相关变化。
Current models of thymic involution propose that intrinsic developmental defects in intrathymic T cell precursors do not contribute to age-related declines in thymopoiesis. This premise was reassessed in a murine model in light of the recent definition of the early T lineage progenitor (ETP), which appears to be the earliest intrathymic precursor defined to date. The results demonstrate that the frequency of ETP declines with age and their potential to reconstitute the thymus is diminished. These findings are consistent with the fact that ETP from aged mice proliferate less and have a higher rate of apoptosis than their counterparts from young animals. Taken together, these data suggest that age-associated changes in T cell precursors should be considered when attempts to rejuvenate the involuted thymus are made.
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胰岛素样生长因子给药和骨髓移植对老年小鼠胸腺生成的影响。
DOI：
10.1210/endo.139.10.6263
发表时间：
1998
期刊：
Endocrinology.
影响因子：
--
作者：
Montecino-Rodriguez,E;Clark,R;Dorshkind,K
通讯作者：
Dorshkind,K
DOI：
10.1073/pnas.83.15.5663
发表时间：
1986-08-01
影响因子：
11.1
作者：
KELLEY, KW;BRIEF, S;WALKER, EB
通讯作者：
WALKER, EB
T 细胞发育的早期阶段受到衰老的影响。
影响因子：
4.3
作者：
Thoman,ML
通讯作者：
Thoman,ML
影响因子：
4.4
作者：
Ortman, CL;Dittmar, KA;Le, PT
通讯作者：
Le, PT