Development of Arterial Blood Supply in Experimental Liver Metastases
Development of Arterial Blood Supply in Experimental Liver Metastases
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DOI：
10.2353/ajpath.2009.090095
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发表时间：
2009-08-01
影响因子：
6
通讯作者：
Paku, Sandor
中科院分区：
文献类型：
--
作者：
Dezso, Katalin;Bugyik, Edina;Paku, Sandor
在这项研究中，我们提出了一个机制的发展动脉血供在实验性肝转移瘤。为了分析实验性肝转移瘤动脉化的过程，我们阐明了小鼠肝小叶血供的几个关键问题。小鼠肝脏的微血管系统的特征在于许多动脉门静脉闭塞和小叶基部的动脉终止。这些终末为每个小叶提供一个肝微循环亚单位，我们称之为动脉肝微循环亚单位（aHMS）。动脉化的过程可分为以下步骤：1）转移导致aHMS变形; 2）aHMS窦状隙在肿瘤实质界面处的初始融合; 3）位于aHMS基部的窦状隙融合，这导致血管括约肌断裂（4）扩张的动脉和融合的血窦进入肿瘤;和5）肿瘤脉管系统的进一步发展通过增殖、重塑和在肿瘤-实质界面处融合的窦状隙的连续并入，可以使肿瘤（动脉树）生长。这一过程导致不可避免的动脉化肝转移瘤以上的2000- 2500 μ m的大小，无论起源和肿瘤的生长模式。(Am J Pathol 2009，175：835-843 DOI：10.2353/ajpath.2009.090095）
In this study, we present a mechanism for the development of arterial blood supply in experimental liver metastases. To analyze the arterialization process of experimental liver metastases, we elucidated a few key questions regarding the blood supply of hepatic lobules in mice. The microvasculature of the mouse liver is characterized by numerous arterioportal anastomoses and arterial terminations at the base of the lobules. These terminations supply one hepatic microcirculatory subunit per lobule, which we call an arterial hepatic microcirculatory subunit (aHMS). The process of arterialization can be divided into the following steps: 1) distortion of the aHMS by metastasis; 2) initial fusion of the sinusoids of the aHMS at the tumor parenchyma interface; 3) fusion of the sinusoids located at the base of the aHMSs, which leads to the disruption of the vascular sphincter (burst pipe); 4) incorporation of the dilated artery and the fused sinusoids into the tumor; and 5) further development of the tumor vasculature (arterial tree) by proliferation, remodeling, and continuous incorporation of fused sinusoids at the tumor-parenchyma interface. This process leads to the inevitable arterialization of liver metastases above the 2000- to 2500-mu m size, regardless of the origin and growth pattern of the tumor. (Am J Pathol 2009, 175:835-843 DOI: 10.2353/ajpath.2009.090095)