Response of Vestibular Nerve Afferents Innervating Utricle and Saccule During Passive and Active Translations
Response of Vestibular Nerve Afferents Innervating Utricle and Saccule During Passive and Active Translations
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DOI：
10.1152/jn.91066.2008
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发表时间：
2009-01-01
影响因子：
2.5
通讯作者：
Cullen, Kathleen E.
中科院分区：
文献类型：
--
作者：
Jamali, Mohsen;Sadeghi, Soroush G.;Cullen, Kathleen E.
Jamali M、Sadeghi SG、Cullen KE。被动和主动翻译过程中支配椭圆囊和球囊的前庭神经传入神经的反应。 《神经生理学杂志》101：141-149，2009 年。首次发表于 2008 年 10 月 29 日； doi：10.1152/jn.91066.2008。区分我们自身行为导致的感觉输入与外部世界变化导致的感觉输入对于感知稳定性和准确的运动控制至关重要。在这项研究中，我们研究了耳石系统在主动和被动翻译过程中线性翻译的编码是否相似。在警觉的猕猴中记录了支配球囊或椭圆囊的前庭神经传入。比较被动全身、被动头对身体和主动头对身体平移（垂直、前后或侧向）期间的单个单元反应，以评估颈部本体感受和输出复制相关信号对翻译编码的相对影响。在被动全身平移与头对身体平移期间，椭圆囊和囊状传入神经的反应动力学是可比较的并且相似编码的头部平移。此外，当猴子产生具有可比动态的主动头对身体翻译时，规则和不规则传入的反应仍然与被动运动期间记录的反应相当。我们的研究结果反驳了这样的观点：颈部本体感觉和/或传出复制由传出系统功能编码的输入，以在主动运动期间调节耳石传入的反应。我们得出的结论是，前庭周边提供了关于头部在空间坐标中的线性运动的忠实信息，无论它们是自身产生的还是外部产生的。
Jamali M, Sadeghi SG, Cullen KE. Response of vestibular-nerve afferents innervating utricle and saccule during passive and active translations. J Neurophysiol 101: 141-149, 2009. First published October 29, 2008; doi:10.1152/jn.91066.2008. The distinction between sensory inputs that are a consequence of our own actions from those that result from changes in the external world is essential for perceptual stability and accurate motor control. In this study, we investigated whether linear translations are encoded similarly during active and passive translations by the otolith system. Vestibular nerve afferents innervating the saccule or utricle were recorded in alert macaques. Single unit responses were compared during passive whole body, passive head-on-body, and active head-on-body translations (vertical, fore-aft, or lateral) to assess the relative influence of neck proprioceptive and efference copy-related signals on translational coding. The response dynamics of utricular and saccular afferents were comparable and similarly encoded head translation during passive whole body versus head-on-body translations. Furthermore, when monkeys produced active head-on-body translations with comparable dynamics, the responses of both regular and irregular afferents remained comparable to those recorded during passive movements. Our findings refute the proposal that neck proprioceptive and/or efference copy inputs coded by the efferent system function to modulate the responses of the otolith afferents during active movements. We conclude that the vestibular periphery provides faithful information about linear movements of the head in the space coordinates, regardless of whether they are self-or externally generated.