Natural extracts as possible protective agents of brain aging
Natural extracts as possible protective agents of brain aging
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DOI：
10.1016/s0197-4580(02)00024-6
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发表时间：
2002-09-01
影响因子：
4.2
通讯作者：
Quirion, R
中科院分区：
文献类型：
--
作者：
Bastianetto, S;Quirion, R
越来越多的研究表明，天然提取物和植物化学物质对大脑衰老有积极的影响。我们研究了银杏叶提取物EGb 761和红葡萄酒衍生成分对β-淀粉样蛋白（Abeta）肽和氧化应激产生的细胞死亡的潜力，以及它们在与年龄相关的神经系统疾病中可能的有害作用。我们发现EGb 761可能通过其黄酮类化合物的抗氧化特性，能够保护海马细胞免受Abeta肽诱导的毒性作用。此外，我们发现，大鼠海马细胞暴露于一氧化氮（NO）供体硝普钠（SNP）导致细胞存活率下降和活性氧（ROS）积累增加。然而，银杏叶提取物761和红葡萄酒衍生的多酚保护免受这些事件，由于其抗氧化活性，并能够阻止SNP刺激的蛋白激酶C（PKC）的活性。综上所述，这些结果支持了这样一种假设，即饮食中摄入天然物质可能有利于大脑的正常衰老。(C)2002年由Elsevier Science Inc.出版
A growing number of studies suggest that natural extracts and phytochemicals have a positive impact on brain aging. We examined the potential of the Ginkgo biloba extract EGb 761 and red wine-derived constituents on cell death produced by beta-amyloid (Abeta) peptides and oxidative stress, with respect to their possible deleterious role in age-related neurological disorders. We found that EGb 761, possibly through the antioxidant properties of its flavonoids, was able to protect hippocampal cells against toxic effects induced by Abeta peptides. Moreover, we showed that an exposure of rat hippocampal cells to the nitric oxide (NO) donor sodium nitroprusside (SNP) resulted in a decrease in cell survival and increase in reactive oxygen species (ROS) accumulation. However, EGb 761 and red wine-derived polyphenols protected against these events, due to their antioxidant activities, and their ability to block SNP-stimulated activity of protein kinase C (PKC). Taken togetherl,these results support the hypothesis that dietary intake of natural substances may be beneficial in normal aging of the brain. (C) 2002 Published by Elsevier Science Inc.