Interactions of helminths with macrophages: therapeutic potential for inflammatory intestinal disease
Interactions of helminths with macrophages: therapeutic potential for inflammatory intestinal disease
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DOI：
10.1080/17474124.2018.1505498
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发表时间：
2018-08
影响因子：
3.9
通讯作者：
Hannah Smith;Ruth Forman;I. Mair;K. Else
中科院分区：
文献类型：
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作者：
Hannah Smith;Ruth Forman;I. Mair;K. Else
摘要引言：巨噬细胞是一种高度异质性和可塑性的细胞类型，存在于身体的大多数组织中;肠道是大量这些细胞的家园。相当大的兴趣围绕着“M2巨噬细胞”，因为它能够控制和调节炎症，同时促进组织修复。涵盖的领域：作为M2巨噬细胞的有效诱导剂，肠道蠕虫和蠕虫衍生产物是用于驱动M2巨噬细胞极化的小分子药物设计的理想候选物。已发现几种胃肠道蠕虫引起M2巨噬细胞诱导感染。这篇综述涵盖了蠕虫产品及其对巨噬细胞极化的影响，这可能会在未来导致新的治疗策略。在PubMed中使用以下检索词进行文献检索：M2巨噬细胞、替代激活、蠕虫产品、蠕虫ES、蠕虫治疗、纳米颗粒、肠巨噬细胞。其他研究通过使用我们原始文献检索识别的文献中的参考文献进行选择。专家评论：虽然寄生虫产品的免疫调节潜力是公认的，但我们还没有完全表征肠道寄生虫产品库的许多组分。目前的工作旨在确定负责调节巨噬细胞和免疫系统其他成分的蛋白质基序。
ABSTRACT Introduction: Macrophages represent a highly heterogeneous and plastic cell type found in most tissues of the body; the intestine is home to enormous numbers of these cells. Considerable interest surrounds the ‘M2 macrophage,’ as it is able to control and regulate inflammation, while promoting tissue repair. Areas covered: As potent inducers of M2 macrophages, intestinal helminths and helminth-derived products are ideal candidates for small molecule drug design to drive M2 macrophage polarization. Several gastrointestinal helminths have been found to cause M2 macrophage-inducing infections. This review covers current knowledge of helminth products and their impact on macrophage polarization, which may in the future lead to new therapeutic strategies. A literature search was performed using the following search terms in PubMed: M2 macrophage, alternative activation, helminth products, helminth ES, helminth therapy, nanoparticle, intestinal macrophages. Other studies were selected by using references from articles identified through our original literature search. Expert commentary: While the immunomodulatory potential of helminth products is well established, we have yet to fully characterize many components of the intestinal helminth product library. Current work aims to identify the protein motifs responsible for modulation of macrophages and other components of the immune system.