Encapsulation of Nicardipine Hydrochloride and Release from Biodegradable Poly(D,L-lactic-co-glycolic acid) Microparticles by Double Emulsion Process: Effect of Emulsion Stability and Different Parameters on Drug Entrapment.
Encapsulation of Nicardipine Hydrochloride and Release from Biodegradable Poly(D,L-lactic-co-glycolic acid) Microparticles by Double Emulsion Process: Effect of Emulsion Stability and Different Parameters on Drug Entrapment.
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DOI：
10.1155/2017/1743765
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发表时间：
2017
影响因子：
3.1
通讯作者：
Thumsing S
中科院分区：
文献类型：
--
作者：
Soomherun N;Kreua-Ongarjnukool N;Chumnanvej S;Thumsing S
聚（D,L-乳酸-乙醇酸）（PLGA）是需要控释时用于药物输送的重要材料。本研究的目的是设计和表征 PLGA 微粒 (PLGA MPs) 植入物，用于体外控制释放盐酸尼卡地平 (NCH)。本研究采用水包油包水 (w1/o/w2) 双乳液和溶剂扩散/蒸发方法制备 PLGA MP。找到了最佳加工条件，例如聚合物含量、表面活性剂类型、稳定剂浓度、内水相和外水相体积以及搅拌速度。用作盐酸尼卡地平（NCH）负载和释放的PLGA MP具有球形形态，平均直径小于5.20±0.25μm。对释放动力学进行建模以阐明药物释放的可能机制。体外释放研究表明，NCH 释放速率缓慢且连续。 PLGA MP 是一种有趣的替代药物输送系统，特别适合与 NCH 一起用于生物医学应用。
Poly(D,L-lactic-co-glycolic acid) (PLGA) is an important material used in drug delivery when controlled release is required. The purpose of this research is to design and characterize PLGA microparticles (PLGA MPs) implants for the controlled release of nicardipine hydrochloride (NCH) in vitro. This study used the water-in-oil-in-water (w1/o/w2) double emulsion and solvent diffusion/evaporation approach to prepare PLGA MPs. Optimal processing conditions were found, such as polymer content, surfactant type, stabilizer concentration, inner and outer aqueous phase volumes, and stirring speed. The PLGA MPs for use as nicardipine hydrochloride (NCH) loading and release had spherical morphology, and the average diameter was smaller than 5.20 ± 0.25 μm. The release kinetics were modeled to elucidate the possible mechanism of drug release. In vitro release studies indicated that the NCH release rate is slow and continuous. PLGA MPs are an interesting alternative drug delivery system, especially for use with NCH for biomedical applications.