Specificity of antinuclear antibodies in scleroderma‐like chronic graft‐versus‐host disease: clinical correlation and histocompatibility locus antigen association
Specificity of antinuclear antibodies in scleroderma‐like chronic graft‐versus‐host disease: clinical correlation and histocompatibility locus antigen association
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抗核抗体在硬皮病样慢性移植物抗宿主病中的特异性：临床相关性和组织相容性位点抗原关联
DOI：
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发表时间：
1996
影响因子：
10.3
通讯作者：
M. Meurer
中科院分区：
文献类型：
--
作者：
Susanne A. Bell;H. Faust;J. Mittermüller;H. Kolb;M. Meurer
骨髓移植后的慢性移植物抗宿主病在少数病例中表现为轻度至重度硬皮病样改变。分析了慢性移植物抗宿主病伴和不伴硬皮病性皮肤变化的患者的抗核自身抗体（ANA）和抗核仁自身抗体（ANoA），结果与疾病症状和组织相容性位点抗原（HLA）模式相关。19例慢性移植物抗宿主病和硬皮病样皮肤变化患者。18例患有慢性移植物抗宿主病，无硬皮病。使用酶联免疫吸附试验、免疫扩散和免疫印迹技术对17名接受免疫抑制治疗的对照进行ANA和ANoA筛查。4例重度硬皮病患者有拓扑异构酶I抗体。两人有抗PM-Scl抗体两者都是特发性系统性硬皮病的特征性血清学发现。1例患者有La/SSB抗体，在3例病例中，可以确定核仁抗原C23（核仁素）的抗体。抗核仁素抗体和疾病活动之间可能存在相关性。HLA-Al - B1与无硬皮病样症状的患者相比，在有硬皮病样症状的患者中发现-B2的频率显著更高。慢性移植物抗宿主病伴硬皮病样表现可能与特发性硬皮病特异性ANA的发生相关。骨髓移植后硬皮病的发展可能具有HLA连锁遗传背景。
Summary Chronic graft‐versus‐host disease after bone marrow transplantation presents, in a few cases, as mild to severe scleroderma‐like changes. Patients with chronic graft‐versus‐host disease with and without sclerodermatous skin changes were analysed for antinuclear autoantibodies (ANA) and antinucleolar autoantibodies (ANoA) and the results correlated with disease symptoms and histocompatibility locus antigen (HLA) pattern. Nineteen patients with chronic graft‐versus‐host disease and scleroderma‐like skin changes. 18 with chronic graft‐versus‐host diseae without scleroderma. and 17 controls on immunosuppressive treatment were screened for ANA and ANoA using enzyme‐linked immunosorbent assay, immunodiffusion and immunoblot techniques. Four patients with severe scleroderma had antibodies to topoisomerase I. two had antibodies against PM‐Scl. both characteristic serological findings in idiopathic systemic scleroderma. One patient had La/SSB antibodies and, in three cases, antibodies to the nucleolar antigen C23 (nucleolin) could be identified. A possible correlation between antinucleolin antibodies and disease activity was observed. HLA‐Al. ‐B1. and ‐B2 were found significantly more often in patients with scleroderma‐like symptoms in comparison to patients without scleroderma‐like symptoms. Chronic graft‐versus‐host disease with seleroderma‐like manifestations can be associated with the occurrence of ANA specific for idiopathic scleroderma. The development of seleroderma after bone marrow transplantation might have a HLA‐linked genetic background.
影响因子：
20.3
作者：
K. Sullivan;H. Shulman;R. Storb;Weiden Pl;R. Witherspoon;G. McDonald;M. Schubert;K. Atkinson;Thomas Ed
通讯作者：
K. Sullivan;H. Shulman;R. Storb;Weiden Pl;R. Witherspoon;G. McDonald;M. Schubert;K. Atkinson;Thomas Ed
系统性红斑狼疮和其他疾病中自身抗体和 DNA/抗 DNA 复合物与新型 110 千道尔顿磷蛋白的反应性。
DOI：
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发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Minota,S;Jarjour,WN;Roubey,RA;Mimura,T;Winfield,JB
通讯作者：
Winfield,JB
影响因子：
3.7
作者：
EGYHAZI, E;PIGON, A;OLSON, MOJ
通讯作者：
OLSON, MOJ