Midlife Obesity and Risk of Frailty in Old Age During a 22-Year Follow-up in Men and Women: The Mini-Finland Follow-up Survey
Midlife Obesity and Risk of Frailty in Old Age During a 22-Year Follow-up in Men and Women: The Mini-Finland Follow-up Survey
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DOI：
10.1093/gerona/glt052
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发表时间：
2014-01-01
影响因子：
5.1
通讯作者：
Koskinen, Seppo
中科院分区：
文献类型：
--
作者：
Stenholm, Sari;Strandberg, Timo E.;Koskinen, Seppo
背景资料。老年虚弱综合征的长期预测因素尚不清楚。与肥胖相关的几种疾病都与虚弱有关。本研究对中年超重和肥胖在22年以上的随访中对虚弱发展的预测作用进行了研究。数据来自参加以人口为基础的迷你芬兰健康检查调查(1978-1980年)并在2000-2001年进行跟踪测量的1119名年龄在30岁或以上但没有体弱的男性和女性。在基线(1978-1980年)时，测量体重和身高。在随访时(2000-2001)，因变量易损性被定义为存在五个脆弱指标中的一个或两个(收缩、虚弱、精疲力竭、缓慢和低体力活动)，而脆弱被定义为三个或更多指标。基线时的平均年龄为43.6(SD 9.7)岁，大多数参与者(95%)年龄在30-60岁之间。易感发生率为5%，虚弱发生率为36%。根据调整后的多项Logistic回归，基线时超重(体重指数25-29.9 kg/m(2))和肥胖(体重指数=30 kg/m(2))的人增加了早衰(优势比1.45，95%可信区间1.08，1.96；优势比2.36，95%可信区间1.41，3.93)和虚弱(优势比2.49，95%可信区间1.22，5.06；在调整了年龄、性别、生活方式因素和慢性病后，随访时与正常体重人群比较的优势比为5.02，95%可信区间为1.89，13.33。虚弱的形成可能在中年就已经开始了，而肥胖是虚弱的潜在原因之一。
Background. Long-term predictors of geriatric syndrome of frailty are unclear. Several obesity-related conditions are associated with frailty. This study examines the predictive role of midlife overweight and obesity on development of frailty more than 22 years of follow-up.Methods. Data are from 1,119 men and women aged 30 or older without frailty at baseline participating in a population-based Mini-Finland Health Examination Survey (1978-1980) with follow-up measurement in 2000-2001. At baseline (1978-1980), body weight and height were measured. At follow-up (2000-2001), the dependent variable prefrailty was defined as the presence of one or two of five frailty indicators (shrinking, weakness, exhaustion, slowness, and low physical activity) and frailty was defined as three or more indicators.Results. The mean age at the baseline was 43.6 (SD 9.7) years, and majority of the participants (95%) were 30-60 years old. Incidence of prefrailty was 5% and frailty 36%. Based on adjusted multinomial logistic regression, persons with overweight (body mass index 25-29.9 kg/m(2)) and obesity (body mass index >= 30 kg/m(2)) at baseline had increased risk of prefrailty (odds ratio 1.45, 95% CI 1.08, 1.96; odds ratio 2.36, 95% CI 1.41, 3.93) and frailty (odds ratio 2.49, 95% CI 1.22, 5.06; odds ratio 5.02, 95% CI 1.89, 13.33) at follow-up in comparison to normal-weight persons after adjusting for age, sex, lifestyle factors and chronic conditions.Conclusions. Development of frailty may start already in midlife, and obesity is one of the underlying causes of frailty.