NORTH AMERICAN BLASTOMYCOSIS: A STUDY OF 40 PATIENTS
NORTH AMERICAN BLASTOMYCOSIS: A STUDY OF 40 PATIENTS
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北美芽生菌病：对 40 名患者的研究
DOI：
10.1097/00005792-196805000-00001
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发表时间：
1968
期刊：
影响因子：
1.6
通讯作者：
J. Utz
中科院分区：
文献类型：
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作者：
P. Witorsch;J. Utz
北美芽孢霉病是由二相性微生物皮炎芽孢杆菌引起的一种系统性真菌病。第一个病人是吉尔克里斯特于1894年()描述的。随后，吉尔-基督和斯托克斯(65，67，68)分离、鉴定并命名了这种致病真菌。这种疾病最初被认为是一种局限性的皮肤感染，但很快就被发现有皮肤外的表现(40，51，66,113,119,166)，到1916年，已报告了47例此类受累(164例)。1939年(100)的文献回顾揭示了347例这种疾病的报告病例。在这些证据中，80个被认为是“毫无疑问”被证明的，163个被认为是“被推定”的。其余104份报告被发现没有足够的证据支持这一诊断。这些作者和其他作者(148)根据当时流行的概念将这种疾病分为两种形式，皮肤和全身，这是基于有两个自然进入门户的概念，肺和皮肤。直到1951年，Schwarz和Baum(135)提出证据支持这一假说，在大多数情况下，在-
North American blastomycosis is a systemic fungal disease produced by the dimorphic micro-organism, Blastomyces dermatitidis. The first patient was described by Gilchrist in 1894 (64). Subsequently, Gil-christ and Stokes (65, 67, 68) isolated, identi-fied, and named the causative fungus. Originally thought to be a localized infection of the skin, the disease was soon recognized to have extracutaneous manifestations (40, 51, 66, 113, 119, 166), and by 1916, 47 cases with such involvement had been reported (164). A review of the literature in 1939 (100) revealed 347 reported cases of this disease. Of these, 80 were regarded as “unquestionably” proved and 163 as “presumptively” so. The remaining 104 reports were found to have in-sufficient evidence to support the diagnosis. These and other authors (148) classified the disease into two forms, cutaneous and systemic, based on the then prevalent concept that there were two natural portals of entry, the lungs and the skin. This dual pathogenesis was generally accepted until 1951, when Schwarz and Baum (135) presented evidence to support the hypothesis that in most cases, in-