"How Sick Must Your Mouse Be?" - An Analysis of the Use of Animal Models in Huntington's Disease Research
"How Sick Must Your Mouse Be?" - An Analysis of the Use of Animal Models in Huntington's Disease Research
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DOI：
10.1177/026119291204000506
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发表时间：
2012-10-01
影响因子：
2.7
通讯作者：
Olsson, I. Anna S.
中科院分区：
文献类型：
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作者：
Franco, Nuno H.;Olsson, I. Anna S.
改善动物福利的改进措施可以缓解神经退行性疾病动物模型研究中人类利益和动物伤害之间的伦理困境。为了评估改进的潜力以及其在研究中的实施，我们分析了1999年至2009年期间发表的关于亨廷顿病（HD）小鼠模型的论文（n = 233）。每项研究都根据动物允许达到的疾病阶段、侵入性程序的执行和细化的实施，根据四级严重程度量表进行分类。在回顾的几年里，伦理批准和法规遵从性的报告总体上呈明显的上升趋势（p < 0.001）。然而，高严重性研究的比例在此期间没有变化。此外，在报告批准的研究中（n = 120），36%的研究被认为是最高严重程度。观察到的差异之间不断上升的动机，以确认监管合规性，和不变的比例的研究，让动物达到严重的痛苦阶段，提出了伦理和方法的问题，我们在本文中讨论。
Refinement measures to improve animal welfare can ease the ethical dilemma between human benefit and animal harm in research with animal models of neurodegenerative diseases. To evaluate the potential for refinement, as well as its implementation in research, we analysed papers on murine models of Huntington's disease (HD) published between 1999 and 2009 (n = 233). Each study was classified according to a four-level severity scale, in terms of the disease stage that animals were allowed to reach, the execution of invasive procedures, and the implementation of refinement. Reports of ethical approval, and regulatory compliance in general, followed a clear rising trend over the years reviewed (p < 0.001). However, the proportion of high-severity studies did not change over that period. Also, of the studies for which approval was reported (n = 120), 36% were attributed the highest severity level. The observed discrepancy between the rising motivation to affirm regulatory compliance, and the unaltered proportion of studies allowing animals to reach severely distressful stages, raises both ethical and methodological issues, which we discuss in this paper.