Tubular organ epithelialisation.
Tubular organ epithelialisation.
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DOI：
10.1177/2041731416683950
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发表时间：
2016-01
影响因子：
8.2
通讯作者：
de Mel A
中科院分区：
文献类型：
--
作者：
Saksena R;Gao C;Wicox M;de Mel A
空心管状器官，包括食道、气管、胃、肠、膀胱和尿道，可能因疾病需要修复或更换。目前的治疗被认为是一个未满足的临床需求，组织工程策略旨在通过制造合成结构作为组织替代物来克服这些问题。智能、功能化的合成材料可以作为器官和多种细胞类型的支架基础，包括干细胞可以用来重新填充这些支架，以替换或修复受损或患病的器官。上皮细胞尚未完全显示出在人造器官中具有有效的细胞-支架相互作用或良好的功能，从而限制了组织工程移植的成功。上皮细胞在各个器官中起着维持其功能的重要作用。没有成功的上皮化，空心器官容易狭窄、塌陷、广泛纤维化和感染，从而限制开放。很明显，细胞来源和支架的物理化学性质决定了上皮化的成功。本文综述了食管、气管、胃、小肠、膀胱和尿道组织工程的研究进展，以实现上皮化移植物。
Hollow, tubular organs including oesophagus, trachea, stomach, intestine, bladder and urethra may require repair or replacement due to disease. Current treatment is considered an unmet clinical need, and tissue engineering strategies aim to overcome these by fabricating synthetic constructs as tissue replacements. Smart, functionalised synthetic materials can act as a scaffold base of an organ and multiple cell types, including stem cells can be used to repopulate these scaffolds to replace or repair the damaged or diseased organs. Epithelial cells have not yet completely shown to have efficacious cell–scaffold interactions or good functionality in artificial organs, thus limiting the success of tissue-engineered grafts. Epithelial cells play an essential part of respective organs to maintain their function. Without successful epithelialisation, hollow organs are liable to stenosis, collapse, extensive fibrosis and infection that limit patency. It is clear that the source of cells and physicochemical properties of scaffolds determine the successful epithelialisation. This article presents a review of tissue engineering studies on oesophagus, trachea, stomach, small intestine, bladder and urethral constructs conducted to actualise epithelialised grafts.