Outcome of Small Lung Nodules Missed on Hybrid PET/MRI in Patients With Primary Malignancy
Outcome of Small Lung Nodules Missed on Hybrid PET/MRI in Patients With Primary Malignancy
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DOI：
10.1002/jmri.25005
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发表时间：
2016-02-01
影响因子：
4.4
通讯作者：
Chandarana, Hersh
中科院分区：
文献类型：
--
作者：
Raad, Roy A.;Friedman, Kent P.;Chandarana, Hersh
目的：评估原发性恶性肿瘤患者同时进行正电子发射断层扫描和磁共振成像（PET/MRI）与参考标准PET和计算机断层扫描（PET/CT）遗漏肺结节的结果。材料和方法：共有208例原发性恶性肿瘤患者接受了临床指征（F-18）氟脱氧葡萄糖（FDG） PET/CT和PET/MRI，由两位读者独立回顾。通过对PET/MRI和PET/CT胸片的检查，43例患者的89个非fdg小结节仅在PET/CT的CT部分检测到（阅读器1），而在PET/MRI上未发现。总的来说，89个结节中的84个在PET/CT或胸部CT的随访成像中进行了检查。其余5个结节没有随访影像学，但有远程影像学可用于比较。结果：在随访的84例结节中，1例患者中有3例（3%）结节进展，10例（12%）结节部分/完全消退，71例（85%）结节保持稳定。未随访的5个结节自先前影像学检查以来均稳定超过21个月。结论：绝大多数（97%）PET/MRI未发现的非fdg小结节在随访中消退或保持稳定，提示良性。尽管PET/MRI在检测小肺结节时灵敏度较低，但它仍然是肿瘤患者可行的替代成像方式。
Purpose: To assess outcomes of lung nodules missed on simultaneous positron emission tomography and magnetic resonance imaging (PET/MRI) compared to the reference standard PET and computed tomography (PET/CT) in patients with primary malignancy.Materials and Methods: In all, 208 patients with primary malignancy undergoing clinically indicated (F-18) fluorodeoxyglucose (FDG) PET/CT followed by PET/MRI were independently reviewed by two readers. Upon review of the thoracic station on PET/MRI and PET/CT, 89 non-FDG avid small lung nodules in 43 patients were detected (by reader 1) only on the CT component of the PET/CT but were not identified on PET/MRI. Overall, 84 of these 89 nodules were examined on follow-up imaging with PET/CT or chest CT. The remaining five nodules had no follow-up imaging but had remote imaging available for comparison.Results: Among the 84 nodules with follow-up, three nodules (3%) in one patient progressed, 10 (12%) nodules partially/completely resolved, whereas 71 nodules (85%) remained stable. The five nodules without follow-up were all stable since prior imaging of over 21 months.Conclusion: The vast majority (97%) of small non-FDG avid lung nodules missed on PET/MRI either resolved or remained stable on follow-up, suggestive of benignity. PET/MRI remains a viable alternative imaging modality in oncology patients, despite its low sensitivity in detecting small lung nodules.