1.7-Micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions-A Feasibility Study.
1.7-Micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions-A Feasibility Study.
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DOI：
10.1109/tmi.2021.3081066
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发表时间：
2021-09
影响因子：
10.6
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Li Y;Murthy RS;Zhu Y;Zhang F;Tang J;Mehrabi JN;Kelly KM;Chen Z
光学相干断层扫描（OCT）是一种非侵入性的诊断方法，提供实时可视化的分层结构的皮肤在体内。1.7微米OCT系统已应用于心脏病学、妇科和皮肤病学，与传统的1.3微米OCT相比，其穿透深度有所改善。为了进一步扩展能力，我们开发了一种1.7微米OCT/OCT血管造影（OCTA）系统，该系统可实现皮肤深层形态和微血管的可视化。使用该成像系统，我们对人体皮肤不同良性病变进行成像，并描述了相应的结构和血管特征。显着改善的成像深度和额外的功能信息表明，1.7微米OCTA系统有很大的潜力，以推进皮肤病学的临床和研究设置的表征良性和癌性皮肤病变。
Optical coherence tomography (OCT) is a non-invasive diagnostic method that offers real-time visualization of the layered architecture of the skin in vivo. The 1.7-micron OCT system has been applied in cardiology, gynecology and dermatology, demonstrating an improved penetration depth in contrast to conventional 1.3-micron OCT. To further extend the capability, we developed a 1.7-micron OCT/OCT angiography (OCTA) system that allows for visualization of both morphology and microvasculature in the deeper layers of the skin. Using this imaging system, we imaged human skin with different benign lesions and described the corresponding features of both structure and vasculature. The significantly improved imaging depth and additional functional information suggest that the 1.7-micron OCTA system has great potential to advance both dermatological clinical and research settings for characterization of benign and cancerous skin lesions.