Effects of different foods on blood glucose and lipid in type 2 diabetes mellitus in a rat model.
Effects of different foods on blood glucose and lipid in type 2 diabetes mellitus in a rat model.
复制标题
不同食物对2型糖尿病大鼠模型血糖和血脂的影响。
DOI：
10.1016/j.jss.2018.02.045
复制
发表时间：
2018
影响因子：
2.2
通讯作者：
S. Weng
中科院分区：
文献类型：
--
作者：
Bin Zhang;Yapeng Yang;B. Luo;S. Weng
本研究探讨了十二指肠-空肠分流术（DJB）和新胆胰分流术（NBPD）对2型糖尿病（T2DM）患者血糖和血脂水平的影响。另一个目标是探索手术治疗T2DM的潜在机制或机制。方法采用高脂、高糖饲料，腹腔注射链脲佐菌素（35 mg/kg）诱导T2DM。然后，将33只T2DM大鼠随机分为三组，DJB组，NBPD组和sham组。测定手术前后空腹体重、空腹血糖和餐后2小时血糖。然后，大鼠分别灌胃脂乳、花生油、葡萄糖、淀粉和安苏，测定血糖和血脂水平。结果DJB组术后1周餐后2 h血糖由术前24.41±2.28 mmol/L降至术后19.87±4.07 mmol/L， NBPD组由术前25.88±1.91 mmol/L降至术后20.34±5.76 mmol/L。脂乳灌胃后，DJB组游离脂肪酸水平从534.60±70.99增加到1082.83±259.67 μEq/L， NBPD组游离脂肪酸水平从648.33±139.26增加到1258.67±204.18 μEq/L。术后DJB组和NBPD组游离脂肪酸水平明显低于假手术组。结论DJB和NBPD术后餐后血糖和血脂下降，可能与术后消化吸收的改变有关。
BackgroundThis study investigated the effects of duodenal-jejunal bypass (DJB) and new biliopancreatic diversion (NBPD) on blood glucose and lipid levels in type 2 diabetes mellitus (T2DM). An additional goal was to explore the potential mechanism or mechanisms underlying the therapeutic effects of surgery on T2DM.MethodsRats were fed a high-fat, high-glucose diet and then were intraperitoneally injected with streptozotocin, 35 mg/kg, to induce T2DM. Then, 33 T2DM rats were randomly assigned to one of three groups, a DJB group, an NBPD group, or a sham group. Fasting body weight, fasting glucose, and 2-h postprandial glucose were measured before and after surgery. Then, the rats were intragastrically administered lipid emulsion, peanut oil, glucose, starch, and Ansul, and blood glucose and lipid levels were measured.ResultsOne week after surgery, 2-h postprandial glucose decreased from 24.41 ± 2.28 mmol/L before surgery to 19.87 ± 4.07 mmol/L after surgery in the DJB group, and from 25.88 ± 1.91 mmol/L before surgery to 20.34 ± 5.76 mmol/L after surgery in the NBPD group. After intragastric administration of lipid emulsion, free fatty acid levels increased from 534.60 ± 70.99 to 1082.83 ± 259.67 μEq/L in the DJB group and from 648.33 ± 139.26 to 1258.67 ± 204.18 μEq/L in the NBPD group. After surgery, free fatty acid levels in the DJB group and NBPD group were significantly lower than those in the sham group.ConclusionsPostprandial blood glucose and lipids decreased after DJB and NBPD, which may be ascribed to postoperative changes in digestion and absorption.