Roles of nucleus accumbens core and shell in incentive-cue responding and behavioral inhibition.
Roles of nucleus accumbens core and shell in incentive-cue responding and behavioral inhibition.
复制标题
DOI：
10.1523/jneurosci.6491-10.2011
复制
发表时间：
2011-05-04
期刊：
影响因子：
--
通讯作者：
Fields HL
中科院分区：
文献类型：
--
作者：
Ambroggi F;Ghazizadeh A;Nicola SM;Fields HL
丘脑核（NAc）参与许多奖赏相关行为。NAc有两个主要组成部分，核心和外壳。这两个区域有不同的输入和输出，表明它们对目标导向行为的贡献不同。使用的歧视性刺激（DS）的任务，在大鼠和失活的NAC阻断兴奋性输入与谷氨酸拮抗剂，我们解离的核心和外壳的贡献任务的表现。NAc核心而不是外壳失活减少响应奖励预测线索。相反，失活的任一子区域诱导一般的行为去抑制。这表明NAc积极抑制不适合DS任务的行为。重要的是，选择性失活的外壳，而不是核心显着增加响应非奖励线索。为了确定NAc核心和外壳的不同贡献是否取决于其组成神经元中编码的信息，我们在执行DS任务的大鼠中进行了电生理记录。虽然没有独特的发射模式，无论是核心或外壳，奖励预测线索引起更频繁和更大幅度的反应，在NAC核心比在外壳。相反，更多的NAc壳神经元选择性地响应非奖励刺激。这些数量上的差异可能解释了需要核心或外壳的不同行为模式。具有相似放电模式的神经元也可能由于其不同的投射目标而对行为产生不同的影响。
The nucleus accumbens (NAc) is involved in many reward-related behaviors. The NAc has two major components, the core and the shell. These two areas have different inputs and outputs suggesting that they contribute differentially to goal-directed behaviors. Using a discriminative stimulus (DS) task in rats and inactivating the NAc by blocking excitatory inputs with glutamate antagonists, we dissociated core and shell contributions to task performance. NAc core but not shell inactivation decreased responding to a reward predictive cue. In contrast, inactivation of either sub-region induced a general behavioral disinhibition. This reveals that the NAc actively suppresses actions inappropriate to the DS task. Importantly, selective inactivation of the shell but not core significantly increased responding to the non-rewarded cue. To determine if the different contributions of the NAc core and shell depend on the information encoded in their constituent neurons, we performed electrophysiological recording in rats performing the DS task. Although there was no firing pattern unique to either core or shell, the reward-predictive cue elicited more frequent and larger magnitude responses in the NAc core than in the shell. Conversely, more NAc shell neurons selectively responded to the non-rewarded stimulus. These quantitative differences might account for the different behavioral patterns that require either core or shell. Neurons with similar firing patterns could also have different effects on behavior due to their distinct projection targets.