Integrating RNA sequencing into neuro-oncology practice.
Integrating RNA sequencing into neuro-oncology practice.
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DOI：
10.1016/j.trsl.2017.06.013
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Koschmann C
中科院分区：
文献类型：
--
作者：
Rogawski DS;Vitanza NA;Gauthier AC;Ramaswamy V;Koschmann C
中枢神经系统（CNS）恶性肿瘤引起大量发病率和死亡率，然而优化化疗和放疗的努力在很大程度上未能改善令人沮丧的预后。在过去的十年中，rna测序（RNA-seq）已经成为一种强大的工具，可以在一个高通量的步骤中全面表征中枢神经系统肿瘤细胞的转录组，从而提高对中枢神经系统肿瘤生物学的理解，并为靶向治疗提供新的途径。RNA-seq在改善脑肿瘤的诊断分类、表征致癌融合基因和揭示肿瘤内异质性方面发挥了重要作用。目前，RNA-seq正开始以精确神经肿瘤学项目的形式被纳入常规的神经肿瘤学实践，这些项目利用肿瘤测序的信息来指导个性化靶向治疗的实施。这些项目在改善单一药物试验无效的肿瘤患者预后方面显示出巨大的希望。由于RNA-seq是一项相对较新的技术，预计未来几年在中枢神经系统肿瘤的研究和治疗中会有许多进一步的应用，取得新的进展。
Malignant tumors of the central nervous system (CNS) cause substantial morbidity and mortality, yet efforts to optimize chemo- and radiotherapy have largely failed to improve dismal prognoses. Over the past decade, RNA-sequencing (RNA-seq) has emerged as a powerful tool to comprehensively characterize the transcriptome of CNS tumor cells in one high-throughput step, leading to improved understanding of CNS tumor biology and suggesting new routes for targeted therapies. RNA-seq has been instrumental in improving diagnostic classification of brain tumors, characterizing oncogenic fusion genes, and shedding light on intra-tumor heterogeneity. Currently, RNA-seq is beginning to be incorporated into regular neuro-oncology practice in the form of precision neuro-oncology programs, which use information from tumor sequencing to guide implementation of personalized targeted therapies. These programs show great promise in improving patient outcomes for tumors where single agent trials have been ineffective. As RNA-seq is a relatively new technique, many further applications yielding new advances in CNS tumor research and management are expected in the coming years.
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影响因子：
7
作者：
Cieslik M;Chugh R;Wu YM;Wu M;Brennan C;Lonigro R;Su F;Wang R;Siddiqui J;Mehra R;Cao X;Lucas D;Chinnaiyan AM;Robinson D
通讯作者：
Robinson D
DOI：
10.1056/nejmoa1407279
发表时间：
2015-06-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Eckel-Passow JE;Lachance DH;Molinaro AM;Walsh KM;Decker PA;Sicotte H;Pekmezci M;Rice T;Kosel ML;Smirnov IV;Sarkar G;Caron AA;Kollmeyer TM;Praska CE;Chada AR;Halder C;Hansen HM;McCoy LS;Bracci PM;Marshall R;Zheng S;Reis GF;Pico AR;O'Neill BP;Buckner JC;Giannini C;Huse JT;Perry A;Tihan T;Berger MS;Chang SM;Prados MD;Wiemels J;Wiencke JK;Wrensch MR;Jenkins RB
通讯作者：
Jenkins RB
DOI：
10.1073/pnas.1507125112
发表时间：
2015-06-09
影响因子：
11.1
作者：
Darmanis S;Sloan SA;Zhang Y;Enge M;Caneda C;Shuer LM;Hayden Gephart MG;Barres BA;Quake SR
通讯作者：
Quake SR
影响因子：
28.2
作者：
Francis JM;Zhang CZ;Maire CL;Jung J;Manzo VE;Adalsteinsson VA;Homer H;Haidar S;Blumenstiel B;Pedamallu CS;Ligon AH;Love JC;Meyerson M;Ligon KL
通讯作者：
Ligon KL
影响因子：
11.5
作者：
Brandes, Alba A.;Franceschi, Enrico;Stupp, Roger
通讯作者：
Stupp, Roger