Inflammation induced by influenza virus impairs human innate immune control of pneumococcus.
Inflammation induced by influenza virus impairs human innate immune control of pneumococcus.
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DOI：
10.1038/s41590-018-0231-y
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发表时间：
2018-12
影响因子：
30.5
通讯作者：
Ferreira DM
中科院分区：
文献类型：
--
作者：
Jochems SP;Marcon F;Carniel BF;Holloway M;Mitsi E;Smith E;Gritzfeld JF;Solórzano C;Reiné J;Pojar S;Nikolaou E;German EL;Hyder-Wright A;Hill H;Hales C;de Steenhuijsen Piters WAA;Bogaert D;Adler H;Zaidi S;Connor V;Gordon SB;Rylance J;Nakaya HI;Ferreira DM
肺炎球菌对上呼吸道的定植既是疾病的决定因素，也是传播到人群中的重要因素。在小鼠身上很好地研究了在定植过程中含有肺炎球菌的免疫学机制，但在人类中仍不清楚。感染流感病毒后肺炎球菌失去这种控制与继发性细菌性肺炎有关。我们使用了6B型肺炎球菌的人类挑战模型来表明，肺炎球菌的获得会导致常驻中性粒细胞的早期脱颗粒和单核细胞向鼻腔的募集。单核细胞功能与肺炎球菌的清除有关。先前鼻部感染减毒活流感病毒会引起炎症，损害先天免疫功能，并改变全基因组鼻部基因对肺炎球菌携带者的反应。在遇到肺炎球菌时，病毒感染促进的细胞因子CXCL10的水平与细菌负荷呈正相关。肺炎球菌在上呼吸道的携带是流感严重程度的重要决定因素。Jochems等人。使用人类系统分析表明，流感引起的炎症增加了鼻腔内的细菌负担，并可能导致继发性细菌性肺炎。
Colonization of the upper respiratory tract by pneumococcus is important both as a determinant of disease and for transmission into the population. The immunological mechanisms that contain pneumococcus during colonization are well studied in mice but remain unclear in humans. Loss of this control of pneumococcus following infection with influenza virus is associated with secondary bacterial pneumonia. We used a human challenge model with type 6B pneumococcus to show that acquisition of pneumococcus induced early degranulation of resident neutrophils and recruitment of monocytes to the nose. Monocyte function was associated with the clearance of pneumococcus. Prior nasal infection with live attenuated influenza virus induced inflammation, impaired innate immune function and altered genome-wide nasal gene responses to the carriage of pneumococcus. Levels of the cytokine CXCL10, promoted by viral infection, at the time pneumococcus was encountered were positively associated with bacterial load. Pneumococcal carriage in the upper respiratory tract is an important determinant of influenza severity. Jochems et al. use human systems analysis to show that influenza-induced inflammation increases bacterial burden in the nasal cavity with implications for secondary bacterial pneumonia.
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影响因子：
5.5
作者：
Lu, Ying-Jie;Leite, Luciana;Goncalves, Viviane Maimoni;Dias, Waldely de Oliveira;Liberman, Celia;Fratelli, Fernando;Alderson, Mark;Tate, Andrea;Maisonneuve, Jean-Francois;Robertson, George;Graca, Rita;Sayeed, Sabina;Thompson, Claudette M.;Anderson, Porter;Malley, Richard
通讯作者：
Malley, Richard
白介素17a介导获得的对肺炎球菌定殖的免疫力。
影响因子：
6.7
作者：
Lu, Ying-Jie;Gross, Jane;Bogaert, Debby;Finn, Adam;Bagrade, Linda;Zhang, Qibo;Kolls, Jay K.;Srivastava, Amit;Lundgren, Anna;Forte, Sophie;Thompson, Claudette M.;Harney, Kathleen F.;Anderson, Porter W.;Lipsitch, Marc;Malley, Richard
通讯作者：
Malley, Richard
影响因子：
6.7
作者：
Jochems SP;Weiser JN;Malley R;Ferreira DM
通讯作者：
Ferreira DM
DOI：
10.1164/rccm.201702-0357oc
发表时间：
2017-11-01
影响因子：
24.7
作者：
Karppinen, Sinikka;Terasjarvi, Johanna;Peltola, Ville
通讯作者：
Peltola, Ville
影响因子：
4.6
作者：
Hoffmann J;Machado D;Terrier O;Pouzol S;Messaoudi M;Basualdo W;Espínola EE;Guillen RM;Rosa-Calatrava M;Picot V;Bénet T;Endtz H;Russomando G;Paranhos-Baccalà G
通讯作者：
Paranhos-Baccalà G