Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells.
Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells.
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DOI：
10.1186/s13045-014-0097-x
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发表时间：
2015-01-29
影响因子：
28.5
通讯作者：
Bae-Jump VL
中科院分区：
文献类型：
--
作者：
Han X;Sheng X;Jones HM;Jackson AL;Kilgore J;Stine JE;Schointuch MN;Zhou C;Bae-Jump VL
高速率的有氧糖酵解是子宫内膜癌细胞消耗葡萄糖作为其主要能量来源的关键机制。上调的糖酵解途径是一种常见的治疗靶点，其抑制对癌细胞的抗肿瘤活性具有影响。本研究旨在评估新型乳酸脱氢酶（LDH）抑制剂没食子黄素作为子宫内膜癌治疗剂的潜力。我们的结果表明，没食子黄素通过参与调节代谢、细胞周期、细胞凋亡、细胞应激和转移的多种信号通路，有效抑制子宫内膜癌细胞系和人子宫内膜癌原代培养物中的细胞生长。本文的在线版本 (doi:10.1186/s13045-014-0097-x) 包含补充材料，可供授权用户使用。
High rates of aerobic glycolysis represent a key mechanism by which endometrial cancer cells consume glucose as its primary energy source. The up-regulated glycolytic pathway is a common therapeutic target whose inhibition has implications for anti-tumor activity in cancer cells. The present study was aimed at evaluating the potential of a novel lactate dehydrogenase (LDH) inhibitor, Galloflavin, as a therapeutic agent for endometrial cancer. Our results revealed that Galloflavin effectively inhibited cell growth in endometrial cancer cell lines and primary cultures of human endometrial cancer through its involvement in multiple signaling pathways that regulate metabolism, cell cycle, apoptosis, cell stress and metastasis. The online version of this article (doi:10.1186/s13045-014-0097-x) contains supplementary material, which is available to authorized users.
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影响因子：
4.5
作者：
Nilsson LM;Forshell TZ;Rimpi S;Kreutzer C;Pretsch W;Bornkamm GW;Nilsson JA
通讯作者：
Nilsson JA
影响因子：
3.4
作者：
Manerba, Marcella;Vettraino, Marina;Recanatini, Maurizio
通讯作者：
Recanatini, Maurizio
DOI：
10.1016/j.bbrc.2012.12.013
发表时间：
2013-01-11
影响因子：
3.1
作者：
Fiume, Luigi;Vettraino, Marina;Brigotti, Maurizio
通讯作者：
Brigotti, Maurizio
影响因子：
4.6
作者：
Farabegoli, F.;Vettraino, M.;Di Stefano, G.
通讯作者：
Di Stefano, G.
影响因子：
4.7
作者：
Dang, Chi V.;Hamaker, Max;Sun, Peng;Le, Anne;Gao, Ping
通讯作者：
Gao, Ping