Synthesis and Evaluation of Water-Soluble Fluorinated Dendritic Block-Copolymer Nanoparticles as a 19F-MRI Contrast Agent
Synthesis and Evaluation of Water-Soluble Fluorinated Dendritic Block-Copolymer Nanoparticles as a 19F-MRI Contrast Agent
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DOI：
10.1002/macp.201000100
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发表时间：
2010-07-15
影响因子：
2.5
通讯作者：
Matsuda, Tetsuya
中科院分区：
文献类型：
--
作者：
Ogawa, Michihiro;Nitahara, Satoshi;Matsuda, Tetsuya
通过聚酰胺胺树枝状大分子引发剂（PAMAM-Br）对甲基丙烯酸2,2,3,3-四氟丙酯（TFPMA）进行活性自由基聚合（LRP），以及羧基甜菜碱单体（CMB）的连续嵌段聚合，成功制备了具有高氟含量和生物相容性的明确水溶性氟化聚合物纳米粒子（PNP）。所获得的核壳型PNPs（PAMAM-g-PTFPMA-b-PCMB）在水中表现出高溶解度，并且在水中具有直径在15-80 nm范围内的球状结构。短 F-19-NMR 自旋晶格弛豫时间 (T-1) (
Well-defined water-soluble fluorinated polymer nanoparticles (PNPs) with a high fluorine content and biocompatibility were successfully prepared by living radical polymerization (LRP) of 2,2,3,3-tetrafluoropropyl methacrylate (TFPMA) from the polyamidoamine dendrimer macroinitiator (PAMAM-Br), and successive block polymerization of carboxybetaine monomer (CMB). The obtained core shell type PNPs (PAMAM-g-PTFPMA-b-PCMB) showed high solubility in water and a sphere-like structure with a diameter in the range of 15-80 nm in water. The short F-19-NMR spin lattice relaxation time (T-1) (