Comparison of cyclosporine nephrotoxicity with aminoglycoside nephrotoxicity.
Comparison of cyclosporine nephrotoxicity with aminoglycoside nephrotoxicity.
复制标题
环孢素肾毒性与氨基糖苷类肾毒性的比较。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
Bennett Wm
中科院分区：
文献类型：
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作者：
Bennett Wm
: Cyclosporine therapy is frequently complicated by dose related nephrotoxicity. In this review, the pharmacology, pathophysiology and clinical features of cyclosporine nephrotoxicity are contrasted with the adverse renal reactions of aminoglycoside antibiotics. From this analysis, it is apparent that these two common nephrotoxins produce renal dysfunction by different mechanisms. Aminoglycosides produce primarily direct toxic effects on the proximal tubular cell while cyclosporine nephrotoxicity is probably predominantly mediated by hemodynamic processes.
