Corticotropin-releasing factor receptor binding in the amygdala changes across puberty in a sex-specific manner.
Corticotropin-releasing factor receptor binding in the amygdala changes across puberty in a sex-specific manner.
复制标题
杏仁核中促肾上腺皮质激素释放因子受体的结合在整个青春期以性别特异性方式发生变化。
作者：
Jill M. Weathington;B. Cooke
促肾上腺皮质激素释放因子受体1型（CRF(1)）和2型（CRF(2)）在控制下丘脑-垂体-肾上腺（HPA）轴方面具有互补作用。因为CRF受体是在前脑的性类固醇敏感区域表达的，它们可能会导致压力敏感的性别特异性模式和对压力相关情绪障碍的易感性，这在女性中更为常见。为了确定CRF受体是否随年龄和/或性别的变化而变化，我们测量了雄性和雌性、青春期前和成年大鼠杏仁核中的受体结合情况。两种受体亚型均表现出年龄和性别特异性结合模式。青春期后，杏仁核基底外侧和后腹侧内侧的CRF(1)结合在男性中减少，在女性中增加；CRF(2)结合在男性中增加，在女性中保持不变。在杏仁核后背部内侧，CRF(1)的结合在整个青春期没有变化，而CRF(2)的结合在整个青春期在男性中比在女性中增加得多。中央杏仁核的结合总体上最低；在那里，CRF(1)在整个青春期没有变化，而CRF(2)的结合仅在男性中增加。因此，在从青春期前到成年的所有四个检测区域中，CRF(2)结合在男性中的增加远远超过女性，并且导致成年男性的结合明显多于成年女性。这些性别特异性的发育模式与下丘脑-垂体-肾上腺反应的性别差异是一致的，因此可能导致情绪障碍易感性的性别差异。
Corticotropin-releasing factor receptors type 1 (CRF(1)) and type 2 (CRF(2)) have complementary roles in controlling the hypothalamic-pituitary-adrenal (HPA) axis. Because CRF receptors are expressed in sex steroid-sensitive areas of the forebrain, they may contribute to sex-specific patterns of stress sensitivity and susceptibility to stress-related mood disorders, which are more frequent in women. To determine whether CRF receptors vary as a function of age and/or sex, we measured receptor binding in the amygdala of male and female, prepubertal and adult rats. Both receptor subtypes demonstrated age- and sex-specific binding patterns. In the basolateral amygdala and posteroventral medial amygdala, CRF(1) binding decreased in males and increased in females after puberty, there, CRF(2) binding increased in males and was unchanged in females. In the posterodorsal medial amygdala, CRF(1) binding was unchanged across puberty, whereas CRF(2) binding increased across puberty far more in males than in females. Binding was lowest overall in the central amygdala; there, CRF(1) was unchanged while CRF(2) binding increased across puberty only in males. Thus, in all four examined areas across prepuberty to adulthood, CRF(2) binding increased far more in males than in females and resulted in significantly more binding in adult males than in adult females. These sex-specific developmental patterns are consistent with sex differences in hypothalamic-pituitary-adrenal responsiveness and may thus contribute to sex differences in mood disorder susceptibility.