Blockage of glucocorticoid, but not mineralocorticoid receptors prevents the persistent increase in circulating basal corticosterone concentrations following stress in the rat
Blockage of glucocorticoid, but not mineralocorticoid receptors prevents the persistent increase in circulating basal corticosterone concentrations following stress in the rat
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DOI：
10.1016/j.neulet.2004.10.016
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发表时间：
2005-02-01
影响因子：
2.5
通讯作者：
Servatius, RJ
中科院分区：
文献类型：
--
作者：
Moldow, RL;Beck, KD;Servatius, RJ
暴露于单一的强烈不可避免的压力源会导致血浆皮质酮水平选择性地升高到昼夜节律的低谷，这种升高在压力源停止后持续数天。在本研究中，我们检查了这种应激引起的昼夜节律谷调节变化是否依赖于应激期间糖皮质激素和/或盐皮质激素受体的激活。在不可避免的应激（1 小时内进行 40、2.0-mA 尾部电击）前 1 小时，用盐皮质激素受体 (MR) 拮抗剂螺内酯（RU-28318；50 mg/kg，皮下注射）和/或糖皮质激素受体 (GR) 拮抗剂米非司酮（RU-38486；50 mg/kg，皮下注射）进行预处理期间）对不可避免的压力的急性血浆皮质酮反应没有影响。单独使用 MR 拮抗剂治疗并不影响应激大鼠基础皮质酮升高的表现。然而，在先前用GR拮抗剂单独或与MR拮抗剂组合治疗的大鼠中，升高的血浆皮质酮谷值不再明显。应激源暴露期间的 GR 激活似乎对于随后基础皮质酮升高的发展是必要的。 (C) 2004 Elsevier Ireland Ltd. 保留所有权利。
Exposure to a single session of intense inescapable stressors results in elevations of plasma corticosterone levels selective to the trough of the circadian rhythm that last for several days after stressor cessation. In the present study, we examined whether this stress-induced alteration in the regulation of the circadian trough is dependent upon glucocorticoid and/or mineralocorticoid receptor activation during stress. Pre-treatment with the mineralocorticoid receptor (MR) antagonist, spironolactone (RU-28318; 50 mg/kg, s.c.), and/or the glucocorticoid receptor (GR) antagonist, mifepristone (RU-38486; 50 mg/kg, s.c.) 1 h before inescapable stress (40, 2.0-mA tail-shocks delivered over a 1 h period) had no effect on the acute plasma corticosterone response to inescapable stress. Treatment with the MR antagonist alone did not affect the appearance of basal corticosterone elevations in stressed rats. However, the elevated trough plasma corticosterone levels were no longer evident in rats treated previously with the GR antagonist either alone or in combination with the MR antagonist. GR activation during stressor exposure appears to be necessary for the development of subsequent basal corticosterone elevations. (C) 2004 Elsevier Ireland Ltd. All rights reserved.