RESPONSES OF NEURONS IN AUDITORY CORTEX OF MACAQUE MONKEY TO MONAURAL AND BINAURAL STIMULATION
RESPONSES OF NEURONS IN AUDITORY CORTEX OF MACAQUE MONKEY TO MONAURAL AND BINAURAL STIMULATION
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DOI：
10.1152/jn.1973.36.6.1138
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发表时间：
1973-01-01
影响因子：
2.5
通讯作者：
MERZENICH, MM
中科院分区：
文献类型：
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作者：
BRUGGE, JF;MERZENICH, MM
实验在10只体重在6至8磅之间的年轻雄性恒河猴(Macaca Mulattu)身上进行，通过无菌手术将三个内螺纹可接受直径0.25英寸的螺栓的无染钢插座植入头骨。它们被隔开，以至于它们一起形成了一个牢固的锚，用于固定头部。一个压克力帽被模制成适合在这些插座上，这样它就可以用三个小螺栓快速而牢固地固定在它们上面。压力帽顶部的短柱可以固定在一个沉重的球窝接头上的连接器上，使头部几乎可以牢固地固定在任何位置。这些动物最初被训练成被束缚在椅子上，戴着帽子，但头部可以自由移动。他们很快就习惯了这一惯例，几天内就会安静地坐在隔音室里8-10个小时。然后，他们的头部被短暂地固定，在连续的日常训练中，时间被延长，直到他们习惯于像这样以舒适的直立姿势坐着长达6-8小时。在这些期间，这些动物被给予食物和饮料，每次训练结束后，它们被送回各自的家庭笼子。猴子们戴着皮领，用一条轻链Ieash牵着。通过一根中空杆拉出这条链子，就可以很容易地控制它们。经过一周左右的训练后，大多数动物都心甘情愿地坐上了束缚椅。所有的猴子都经历了至少一个月的这种条件反射过程，当记录实验开始时，它们的头被僵硬地固定了几个小时，没有任何痛苦的迹象。在动物被调理后，使用无菌手术程序将一个Lucite小室安装在头骨的外侧。这个腔体用两个固定在头骨上。
Experiments were conducted on 10 young male rhesus monkeys (Macaca mulattu) weighing between 6 and 8 pounds, Three stainXess steel sockets, threaded on the inside to accept 0.25-inch-diameter bolts, were implanted into the skull using sterile operative procedures. They were spaced so that together they formed a firm anchor for immobilizing the head. An acrylic cap was molded to fit over these sockets in such a way that it could be quickly and firmly fastened to them with the three small bolts. A short post on top of the acrylic cap could be fastened to a connector on a heavy ball-and-socket joint allowing the head to be firmly fixed in almost any position. The animals were first trained to sit restrained in a chair with the cap on but with the head free to move. They quickly became accustomed to this routine and within a few days would sit quietly in a soundproof room for 8-10 hr. Their head was then immobilized for a short period of time, and in successive daily sessions the time was lengthened until they were accustomed to sitting like this in a comfortable upright posture for as long as 6-8 hr. The animals were given food and drink during these periods and after each training session they were returned to their individual home cages. The monkeys wore leather collars and were handled on a light chain Ieash. By drawing this chain through a hollow rod they could be easily controlled. Most animals moved willingly into the restraining chair after a week or so of conditioning. All monkeys underwent this conditioning procedure for at least 1 month, and when recording experiments began they tolerated having their heads rigidly fixed for several hours without signs of distress. After the animal was conditioned a Lucite chamber was mounted over the lateral aspect of the skull using sterile operative procedures. The chamber was fastened to the skull with two