SURFACTANTS IDENTIFIED IN SYNOVIAL-FLUID AND THEIR ABILITY TO ACT AS BOUNDARY LUBRICANTS
SURFACTANTS IDENTIFIED IN SYNOVIAL-FLUID AND THEIR ABILITY TO ACT AS BOUNDARY LUBRICANTS
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DOI：
10.1136/ard.43.4.641
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发表时间：
1984-01-01
影响因子：
27.4
通讯作者：
BUTLER, BD
中科院分区：
文献类型：
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作者：
HILLS, BA;BUTLER, BD
TLC已用于鉴定从犬滑液中提取的磷脂，主要成分（45%）为磷脂酰胆碱（PC）。提取物及其组分已被证明在降低水的表面张力方面具有表面活性，并且易于吸附到亲水性固体上，然后其表面变得疏水。这些吸附的滑膜表面活性剂单层在体外是优异的边界润滑剂，降低了动摩擦系数（μ）。在干燥状态和生理负荷下，对于提取物高达97%，对于单独的PC高达99%，达到μ g/ml。= 0.01。表面活性磷脂被提出作为关节润滑的可能活性成分，并显示与以前的生化研究一致，以阐明其身份。该模型基本上遵循经典的哈代模型的边界润滑表面活性剂受损。它是讨论有关一种新的方法，在提供人工润滑和促进组织释放关节炎患者。
TLC has been used to identify phospholipids extracted from canine synovial fluid, the major component (45%) being phosphatidyl choline (PC). The extracts and their components have been shown to be surface active in reducing the surface tension of water and to be readily adsorbed to hydrophilic solids, whose surfaces then become hydrophobic. These adsorbed monolayers of synovial surfactant were excellent boundary lubricants in vitro, reducing the coefficient of kinetic friction (.mu.) in the dry state and under physiological loading by up to 97% for extracts and 99% for PC alone, reaching .mu. = 0.01. Surface-active phospholipid is put forward as the possible active ingredient in joint lubrication and shown to be consistent with previous biochemical studies to elucidate its identity. The model essentially follows the classical Hardy model for boundary lubrication impaired by surfactants. It is discussed in relation to a new approach in providing artificial lubrication and facilitating tissue release in patients with arthritis.