Effect of vitiligo on self-reported health-related quality of life
Effect of vitiligo on self-reported health-related quality of life
复制标题
DOI：
10.1111/j.1365-2133.2005.06456.x
复制
发表时间：
2005-06-01
影响因子：
10.3
通讯作者：
Naeyaert, JM
中科院分区：
文献类型：
--
作者：
Ongenae, K;Van Geel, N;Naeyaert, JM
背景白癜风是一种色素性疾病，影响至少1%的总人口。虽然这种疾病不会造成直接的身体损害，但它可能会大大影响患者的心理健康。有人认为，患者自尊心低，身体形象差，生活质量差。大多数关于白癜风的社会心理影响的研究是在美国进行的。S. A.目的本研究旨在通过评估比利时荷语区（弗兰德斯）人群的健康相关生活质量来量化白癜风的负担。这是比较残疾的水平所造成的牛皮癣在类似的招募人口。这也是我们的目的，以检测那些在经历一个穷人的生活质量的风险，并确定变量，可能会预测这种impairment.Patients和方法白癜风患者（n = 119）和162例银屑病患者被列入邮政调查。为了获得基于患者的生活质量测量，我们使用了皮肤病生活质量指数（DLQI），这是一种经过广泛验证的问卷，易于使用，并可以比较几种皮肤病。其他调查问题与人口统计学数据和疾病相关的characteristics.Results我们在两个患者组中获得了极好的应答率。白癜风的DLQI总平均评分（4.95）低于银屑病（6.26）（P = 0.01）。白癜风患者在症状和治疗方面对生活质量的影响均较轻（P < 0.001）。白癜风的最高个体平均得分为Q2（感觉），Q4（服装），Q5（社交和休闲活动）和Q3（日常生活）。疾病和性别对DLQI评分的交互作用非常显著（P = 0.001）。虽然男性白癜风患者的DLQI评分显著低于男性银屑病患者（P < 0.001），但我们发现这些疾病组中女性的DLQI评分总体上相当。咨询次数（P = 0.005）和疾病严重程度（P < 0.001）与DLQI独立相关。结论我们的研究量化了白癜风对生活质量造成的负担，并指出了患者生活中最受疾病影响的特定领域。性别、就诊次数和主观疾病严重程度独立预测生活质量。在我们的研究人群中，白癜风女性患者的生活质量损害与银屑病引起的损害相同。这些结果应该唤醒医生对这种“美容”疾病的兴趣，因为适当的治疗可能会改善白癜风患者的生活质量。
Background Vitiligo is a pigmentary disorder affecting at least 1% of the total population. Although the disease does not produce direct physical impairment, it may considerably influence the psychological well-being of the patients. It has been suggested that patients suffer from low self-esteem, poor body image and a poor quality of life. The majority of the studies on the psychosocial impact of vitiligo were conducted in the U. S. A. and England.Objectives This study aims to quantify the burden of vitiligo by estimating health-related quality of life in the Dutch-speaking Belgian population (Flanders). This is compared with the level of disability caused by psoriasis in a similarly recruited population. It is also our purpose to detect those at risk of experiencing a poor quality of life and to identify variables that might predict this impairment.Patients and methods Patients with vitiligo (n = 119) and 162 patients with psoriasis were included in a postal survey. In order to obtain a patient-based measurement of quality of life we used the Dermatology Life Quality Index (DLQI), a widely validated questionnaire that is easy to use and allows comparison between several skin disorders. Other survey questions were related to demographic data and disease-related characteristics.Results We obtained excellent response rates in both patient groups. The overall mean DLQI score for vitiligo (4.95) was lower than that for psoriasis (6.26) (P = 0.01). Patients with vitiligo experienced significantly less impairment of life quality from the symptoms and treatment of the disease (P < 0.001). The highest individual mean scores in vitiligo were found for Q2 (feelings), Q4 (clothing), Q5 (social and leisure activities) and Q3 (daily routine). The interaction of disease and sex on the DLQI score was highly significant (P = 0.001). While men with vitiligo scored significantly lower than men with psoriasis (P < 0.001), we found a comparable overall DLQI score for women in these disease groups. The number of consultations (P = 0.005) and severity of the disease (P < 0.001) were independently related to the DLQI.Conclusions Our study quantifies the burden on the quality of life caused by vitiligo and indicates specific areas of patients' lives which are most affected by the disease. Sex, number of consultations and subjective disease severity independently predict the quality of life. The quality of life impairment in women affected with vitiligo equals the impairment caused by psoriasis in our study population. These results should awake the interest of physicians in this 'cosmetic' disease, since appropriate treatment is likely to improve the quality of life of vitiligo patients.