Predicting odorant quality perceptions from multidimensional scaling of olfactory bulb glomerular activity patterns
Predicting odorant quality perceptions from multidimensional scaling of olfactory bulb glomerular activity patterns
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DOI：
10.1037/0735-7044.120.6.1337
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发表时间：
2006-12-01
影响因子：
1.9
通讯作者：
Kent, Paul F.
中科院分区：
文献类型：
--
作者：
Youngentob, Steven L.;Johnson, Brett A.;Kent, Paul F.
气味和它们的感知在沿着多个维度上是不同的，这就要求对任何假定的神经代码进行批判性检查，直接评估编码过程的多维度性质。以前的工作已经研究了简单的，系统的气味差异，无论编码策略，预计将产生简单的，系统的预测神经和行为反应。在本研究中，气味识别混淆矩阵任务，提取精确的质量关系的气味被用来确定是否空间特定的肾小球活动模式预测感知质量关系的气味，不能很容易地被归类为先验沿着一个单一的化学尺寸。通过比较[C-14]-2-脱氧葡萄糖肾小球活动模式数据得出的气味模式相似性测量值的多维标度（MDS）分析产生了二维气味活动空间，该空间高度显着地预测了类似获得的气味感知空间，并且在动物中一致。这些结果强烈支持相关的全球空间格局的嗅球编码的气味质量。
Odorants and their perceptions differ along multiple dimensions, requiring that a critical examination of any putative neural code directly assess the multidimensional nature of the encoding process. Previous work has examined simple, systematic odorant differences that, regardless of coding strategy, would be expected to produce simple, systematic predictions in neural and behavioral responses. In the present study, an odorant identification confusion matrix task that extracts precise quality relationships across odorants was used to determine whether spatially specific glomerular activity patterns predict perceptual quality relationships for odorants that cannot easily be classified a priori along a single chemical dimension. Multidimensional scaling (MDS) analysis of odorant pattern similarity measures derived from the comparison of [C-14]-2-deoxyglucose glomerular activity pattern data yielded a two-dimensional odorant activity space that was highly significantly predictive of similarly obtained odorant perceptual spaces, uniformly across animals. These results strongly support the relevance of global spatial patterns in the olfactory bulb to the encoding of odor quality.