Single-Stimulus Dual-Drug Sensitive Nanoplatform for Enhanced Photoactivated Therapy
Single-Stimulus Dual-Drug Sensitive Nanoplatform for Enhanced Photoactivated Therapy
复制标题
用于增强光激活治疗的单刺激双药物敏感纳米平台
DOI：
10.1021/acs.biomac.6b00353
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发表时间：
2016-06-01
影响因子：
6.2
通讯作者：
Huang, Yubin
中科院分区：
文献类型：
--
作者：
He, Shasha;Qi, Yanxin;Huang, Yubin
光活化疗法已成为传统癌症治疗的补充和有吸引力的方式。在此，我们展示了一种新的单刺激双药物敏感的纳米平台，用于增强光活化治疗的Cur-负载的Dex-Pt（N-3）纳米颗粒（Cur@ DPN）。所开发的Cur@ DPN可以被UVA光活化，以同时从Cur产生即时活性氧物质用于快速光动力学治疗，并从Pt（N-3）释放持久的Pt（II）用于长效光化学疗法。与小分子游离药物和单独光活化治疗相比，Cur@ DPN具有增强的光活化细胞毒性和体内抗肿瘤功效，同时伴有较低的全身毒性。因此，单刺激双药物敏感纳米平台是一种有前途的多药物递送、位点选择性和组合光活化治疗策略。
Photoactivated therapy has become a complementary and attractive modality for traditional cancer treatment. Herein, we demonstrated a novel single-stimulus dual-drug sensitive nanoplatform, Cur-loaded Dex-Pt(N-3) nanopartides (Cur@DPNs) for enhanced photoactivated therapy. The developed Cur@DPNs could be photoactivated by UVA light to simultaneously generate instant reactive oxygen species from Cur for fast photodynamic therapy and release lasting Pt(II) from Pt(N-3) for long-acting photochemotherapy. Compared with small free drugs and individual photoactivated therapy, Cur@DPNs exhibited enhanced photoactivated cytotoxicity and in vivo antitumor efficacy with low systemic toxicity accompanied. Therefore, the single-stimulus dual-drug sensitive nanoplatform is convinced to be a promising strategy for multidrug delivery, site-selective and combinational photoactivated therapy in the near future.