Early myelination patterns in the brainstem auditory nuclei and pathway: MRI evaluation study
Early myelination patterns in the brainstem auditory nuclei and pathway: MRI evaluation study
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DOI：
10.1016/j.ijporl.2007.04.002
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发表时间：
2007-07-01
影响因子：
1.5
通讯作者：
Mima, Kazuo
中科院分区：
文献类型：
--
作者：
Sano, Masaki;Kaga, Kimitaka;Mima, Kazuo
目的：探讨脑干听觉核团的早期髓鞘形成模式及其磁共振成像途径，并与以往的组织学研究进行比较。我们的目的是确定脑干听觉核团髓鞘形成的时程差异和磁共振成像与组织学研究结果之间的路径。方法：受试者为192名婴儿，年龄从-4到224周龄矫正后出生。使用1.5T磁共振装置获得图像。在脑干听觉核团的4个部位(耳蜗核、上橄榄核、外侧丘核、下丘)和与脑干长轴垂直的4个横断面上，用感兴趣区方法分析T1和T2加权像的信号变化。结果：耳蜗核和上橄榄核在-3~13周龄的T2加权像上表现为有髓信号的变化。外侧丘系在T1加权像上为-3~8周，在T2加权像上为-1~13周。在T2加权像上，下丘在-2~39周的校正后表现为有髓信号的变化。结论：磁共振成像显示髓鞘信号的变化比组织学文献报道的晚11-18周。提示除组织学研究外，MRI评价脑干听觉通路发育除组织学研究外，还应考虑利用MRI评价听觉通路成熟的里程碑。这一结果提示髓鞘形成不是突然发生的，而是逐渐发生的，因此需要通过磁共振成像来检测明确的髓鞘形成，即髓鞘成分的完全改变、水分的丢失和脂质的增加。(C)2007爱思唯尔爱尔兰有限公司。保留所有权利。
Objective: The purpose of this study is to investigate the early myelination patterns of brainstem auditory nuclei and pathway on magnetic resonance imaging compared with past histological research. We aimed to identify the time course difference in myelination of the brainstem auditory nuclei and pathway between magnetic resonance imaging and histological research results.Methods: Subjects were 192 infants ranging in age from -4 to 224 corrected post-natal weeks. Images were obtained using a 1.5 T magnetic resonance unit. In four sites (cochlear nucleus, superior olivary nucleus, lateral lemniscus, inferior colliculus) of the brainstem auditory nuclei and pathway on four cross-sections obtained perpendicular to the long axis of the brainstem, signal changes of T1- and T2-weighted magnetic resonance images were analyzed using a region-of-interest methodology according to corrected postnatal age.Results: The cochlear nucleus and superior olivary nucleus showed myelinated intensity change from -3 to 13 corrected postnatal weeks on T2-weighted images. The lateral lemniscus showed myelinated intensity change from -3 to 8 corrected postnatal weeks on T1-weighted images and from -1 to 13 corrected postnatal weeks on T2-weighted images. The inferior colliculus showed myelinated intensity change from -2 to 39 corrected postnatal weeks on T2-weighted images.Conclusions: Magnetic resonance imaging revealed the signal intensity change by myelination 11-18 weeks later than those reported in the histological literature. This time tag suggests that apart from histological research, the necessity for the milestones of auditory pathway maturation using MRI is suggested to evaluate the development of brainstem auditory pathway using MRI. This result suggests that myelination does not take place suddenly but happens gradually, so definite myelination, namely the complete change of myelin sheath ingredients, loss of water, and gain of lipids, is needed to be detected by magnetic resonance imaging. (C) 2007 Elsevier Ireland Ltd. All rights reserved.