Evidence for muscarinic acetylcholine receptor subtypes in the pigeon telencephalon.
Evidence for muscarinic acetylcholine receptor subtypes in the pigeon telencephalon.
复制标题
鸽子端脑中毒蕈碱乙酰胆碱受体亚型的证据。
DOI：
10.1002/cne.903620209
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Bingman,VP
中科院分区：
文献类型：
--
作者：
Kohler,EC;MesserJr,WS;Bingman,VP
At least five subtypes of muscarinic acetyicholine receptors are expressed in various mammalian tissue preparations. The following experiment, through the use of direct binding assays (using tritiated quinuclidinyl benzilate), competitive binding assays (using tritiated quinuclidinyl benzilate and unlabeled pirenzepine or AF‐DX 116), and autoradiographic techniques, examined whether two of these five putative muscarinic acetylcholine receptor subtypes can be found in avian brain. Accordingly, autoradiographic mapping of pirenzepine sensitive (M1‐like) and AF‐DX 116‐sensitive (M2‐like) muscarinic acetylcholine receptor subtypes in the pigeon telencephalon was condu Although both ligands bound throughout the brain, most telencephalic regions, including the archistriatum, the neostriatum, and basal ganglia structures like lobus paraolfactorius, nucleus accumbens, and paleostriatum, showed a higher density of M1‐like sites. The exception to this finding was the nucleus basalis which appeared as a region where M2‐like sites predominated. Moreover, the telencephalic region with the largest ratio of M1‐like to M2‐like sites was the lateral portion of the parahippocampus; a characteristic shared with the mammalian dentate gyrus. The findings reported here are generally consistent with previous reports of mammalian M1/M2 receptor distributions. © Wiley‐Liss, Inc.
