Vision in dementia: Contrast effects
Vision in dementia: Contrast effects
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DOI：
10.1080/01616412.1996.11740369
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发表时间：
1996-02-01
影响因子：
1.9
通讯作者：
Shankle, R
中科院分区：
文献类型：
--
作者：
Lakshminarayanan, V;Lagrave, J;Shankle, R
对比敏感度在阿尔茨海默病(AD)中受到影响。我们使用临床测试图表对这一人群的低对比敏锐度和对比敏感度进行了调查。此外，我们还测试了血管性痴呆(Vd)和混合性痴呆(Md)患者(阿尔茨海默病合并血管性痴呆)。对比敏感度使用Vistech VCTs 6500测试表进行评估。使用Regan表在四个对比度水平(96%、50%、25%和11%)测量低对比度视力。AD患者19例，VD患者9例，MD患者10例。所有病例的视力均随着对比度的升高而降低。对数据进行回归直线拟合，并进行统计学分析。我们没有发现在AD组和VD或MD组之间有统计学意义的差异。然而，我们确实发现了VD组和MD组之间的差异。我们确实发现，与老年正常人相比，所有空间频率的对比度敏感度都有所降低。相应地，我们发现，在测试的四个对比度水平上，与正常数据相比，视力有显著差异。在所有患者组中，视力随着对比度的降低而降低。我们的对比敏感度结果与文献报道的结果相似。这项研究指出了使用简单的临床测试图表的重要性，并进一步强调了广告中存在初级视觉缺陷的观点。
Contrast sensitivity has been shown to be affected in Alzheimer's disease (Ad). We investigated low contrast acuity and contrast sensitivity using clinical test charts in this patient population. Additionally, we tested patients with vascular dementia (vd) and mixed dementia (md), (Alzheimer' with vascular dementia). Contrast sensitivity was assessed using the Vistech VCTS 6500 test chart. Low contrast acuity was measured using the Regan charts at four contrast levels (96%, 50%, 25% and 11%). The patient population consisted of 19 Ad patients, 9 vd patients and 10 md patients. Reduction in acuity was found with contrast level in all cases. Regression lines were fit to the data and statistical analysis was performed. We did not find a statistically significant difference between the Ad and vd or md groups. We did, however, find a difference between the vd and md groups. We did find reduction in contrast sensitivity at all spatial frequencies when compared to the elderly normal. Correspondingly, we found a significant difference in acuity when compared with normal data at-the four contrast levels tested. Acuity is reduced with contrast in all patient groups. Our contrast sensitivity results are similar to those reported in the literature. This study points out the importance of using simple clinical test charts and further underscores the idea that there is a primary Visual deficit in Ad.