Association Between Menstrual Cycle Length and Coronavirus Disease 2019 (COVID-19) Vaccination: A U.S. Cohort.
Association Between Menstrual Cycle Length and Coronavirus Disease 2019 (COVID-19) Vaccination: A U.S. Cohort.
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DOI：
10.1097/aog.0000000000004695
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发表时间：
2022-04-01
影响因子：
7.2
通讯作者：
Darney BG
中科院分区：
文献类型：
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作者：
Edelman A;Boniface ER;Benhar E;Han L;Matteson KA;Favaro C;Pearson JT;Darney BG
根据前瞻性人群水平数据，2019冠状病毒病（COVID-19）疫苗接种与月经周期长度的变化小于1天相关，但月经长度没有变化。评估与未接种疫苗的队列相比，接种2019冠状病毒病（COVID-19）疫苗是否与接受疫苗接种的人群的月经周期或月经长度变化相关。我们使用应用程序“自然周期”分析了前瞻性跟踪的月经周期数据。我们纳入了18-45岁的美国居民，他们在第一次疫苗接种前连续三个周期的正常周期长度（24-38天），然后是疫苗接种周期（4-6个周期），或者如果未接种疫苗，则在类似的时间段内进行六个周期。我们计算了周期和月经长度的平均个体内变化（接种疫苗队列中的三个接种前周期与第一和第二剂量周期，以及未接种疫苗队列中的前三个周期与第四和第五周期）。我们使用混合效应模型来估计接种疫苗和未接种疫苗队列之间的月经周期和月经长度变化的调整差异。我们纳入了3，959人（接种疫苗2，403人;未接种疫苗1，556人）。大多数接种队列接受了Pfizer-BioNTech疫苗（55%）（Moderna 35%，约翰逊&约翰逊/杨森7%）。总体而言，与接种前周期相比，COVID-19疫苗的两个疫苗剂量周期的周期长度变化均小于1天（首次给药0.71天增加，98.75% CI 0.47-0.94;第二次给药0.91，98.75% CI 0.63-1.19）;与三个基线周期相比，未接种疫苗的个体没有显著变化（第4周期0.07，98.75% CI −0.22至0.35;第5周期0.12，98.75% CI −0.15至0.39）。在校正模型中，两种剂量下接种疫苗和未接种疫苗队列之间的周期长度变化差异均小于1天（变化差异：第一剂0.64天，98.75% CI 0.27-1.01;第二剂0.79天，98.75% CI 0.40-1.18）。月经长度的变化与疫苗接种无关。2019冠状病毒病（COVID-19）疫苗接种与周期长度的微小变化有关，但与月经长度无关。
Based on prospective population-level data, coronavirus disease 2019 (COVID-19) vaccination is associated with a less than 1-day change in menstrual cycle length but no change in menses length. To assess whether coronavirus disease 2019 (COVID-19) vaccination is associated with changes in cycle or menses length in those receiving vaccination as compared with an unvaccinated cohort. We analyzed prospectively tracked menstrual cycle data using the application “Natural Cycles.” We included U.S. residents aged 18–45 years with normal cycle lengths (24–38 days) for three consecutive cycles before the first vaccine dose followed by vaccine-dose cycles (cycles 4–6) or, if unvaccinated, six cycles over a similar time period. We calculated the mean within-individual change in cycle and menses length (three prevaccine cycles vs first- and second-dose cycles in the vaccinated cohort, and the first three cycles vs cycles four and five in the unvaccinated cohort). We used mixed-effects models to estimate the adjusted difference in change in cycle and menses length between the vaccinated and unvaccinated cohorts. We included 3,959 individuals (vaccinated 2,403; unvaccinated 1,556). Most of the vaccinated cohort received the Pfizer-BioNTech vaccine (55%) (Moderna 35%, Johnson & Johnson/Janssen 7%). Overall, COVID-19 vaccine was associated with a less than 1-day change in cycle length for both vaccine-dose cycles compared with prevaccine cycles (first dose 0.71 day-increase, 98.75% CI 0.47–0.94; second dose 0.91, 98.75% CI 0.63–1.19); unvaccinated individuals saw no significant change compared with three baseline cycles (cycle four 0.07, 98.75% CI −0.22 to 0.35; cycle five 0.12, 98.75% CI −0.15 to 0.39). In adjusted models, the difference in change in cycle length between the vaccinated and unvaccinated cohorts was less than 1 day for both doses (difference in change: first dose 0.64 days, 98.75% CI 0.27–1.01; second dose 0.79 days, 98.75% CI 0.40–1.18). Change in menses length was not associated with vaccination. Coronavirus disease 2019 (COVID-19) vaccination is associated with a small change in cycle length but not menses length.