Expression and clinical significance of insulin-like growth factor 1 in lung cancer tissues and perioperative circulation from patients with non-small-cell lung cancer
Expression and clinical significance of insulin-like growth factor 1 in lung cancer tissues and perioperative circulation from patients with non-small-cell lung cancer
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DOI：
10.3747/co.23.2669
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发表时间：
2016-02-01
期刊：
影响因子：
2.6
通讯作者：
Fu, X.
中科院分区：
文献类型：
--
作者：
Fu, S.;Tang, H.;Fu, X.
目的探讨胰岛素样生长因子1（IGF-1）在肺癌发生发展中的作用。方法采用免疫组化法检测80例原发性非小细胞肺癌（NSCLC）和45例肺良性病变（BPLS）组织及围手术期循环中IGF-1及其受体（IGF-1 R）的表达。分析这些测量值与临床病理特征和临床随访的相关性。结果NSCLC组织中IGF-1和IGF-1 R的表达均高于BPL组织（P < 0.001）。IGF-1和IGF-1 R的表达水平与晚期疾病（分别为p = 0.034和0.029）和淋巴结转移（分别为p = 0.012和0.017）显著相关，IGF-1的表达与肿瘤分化和肿瘤直径相关（分别为p = 0.011和0.021）。IGF-1或IGF-1 R阳性标本与较短的患者生存期显著相关（分别为p = 0.0012和0.0016）。手术后，BPL患者的循环IGF-1显著升高，（p = 0.0346），NSCLC患者显著较低（p = 0.0030），尤其是在晚期疾病、肿瘤较大、区域淋巴结转移或分化程度较低的患者中结论IGF-1和IGF-1 R在NSCLC中表达上调，其表达与NSCLC的进展和预后相关。非小细胞肺癌的根治性切除可直接影响血清IGF-1的浓度。自分泌/旁分泌IGF-1可能在肺癌的发生发展中起重要作用。
Objective We explored the role of insulin-like growth factor 1 (IGF-1) in the development of lung cancer.Methods We used immunohistochemistry to measure the expression of IGF-1 and IGF-1 receptor (IGF-1R) in specimens of tissue and perioperative circulation from 80 patients with primary non-small-cell lung cancer (NSCLC) and from 45 patients with benign pulmonary lesions (BPLS). Correlations of those measurements with clinicopathologic characteristics and clinical follow-up were analyzed. Circulating IGF-1 was measured before and after surgery in all patients.Results Compared with BPL specimens, NSCLC specimens showed overexpression of IGF-1and IGF-1R (p < 0.001). The expression levels of IGF-1 and IGF-1R were significantly associated with advanced-stage disease (p = 0.034 and 0.029 respectively) and lymph node metastasis (p = 0.012 and 0.017 respectively), and expression of IGF-1 correlated with tumour differentiation and tumour diameter (p = 0.011 and 0.021 respectively). Specimens positive for IGF-1 or IGF-1R were significantly correlated with shorter patient survival (p = 0.0012 and 0.0016 respectively). After surgery, circulating IGF-1 was significantly elevated in patients with BPL (p = 0.0346) and significantly lower in patients with NSCLC (p = 0.0030), especially in those with advanced-stage disease, a larger tumour size, regional lymphoid node metastasis, or lesser differentiation (p = 0.0092, 0.0051, 0.0131, and p < 0.001 respectively).Conclusions In NSCLC, IGF-1 and IGF-1R are upregulated, and expression of those factors is correlated with tumour progression and prognosis in NSCLC patients. Radical resection of NSCLC can directly influence the serum concentration of IGF-1. Autocrine/paracrine IGF-1 might be playing an important role in the development of lung cancer.