Neogenin: A multi-functional receptor regulating diverse developmental processes
Neogenin: A multi-functional receptor regulating diverse developmental processes
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DOI：
10.1016/j.biocel.2006.11.009
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发表时间：
2007-01-01
影响因子：
4
通讯作者：
Cooper, Helen M.
中科院分区：
文献类型：
--
作者：
Cole, Stacey J.;Bradford, DanaKai;Cooper, Helen M.
再生蛋白是结直肠癌（DCC）中轴突导向受体β的近亲，已被证明是Netrin和排斥导向分子（RGM）家族成员的受体。虽然Netrin-1-再生蛋白相互作用导致chernotractive轴突引导反应，但再生蛋白和RGMa之间的相互作用诱导化学排斥反应。现在越来越多的证据表明再生素是一种多功能受体，调节许多不同的发育过程，包括神经管和乳腺形成，肌肉发生和血管生成。再生素在成年人中的功能知之甚少，然而，现在正在出现一种新的铁稳态调节作用。虽然再生蛋白激活的信号转导途径知之甚少，但很明显，再生蛋白激活的功能结果，至少在胚胎中，取决于发育背景以及配体的性质。(c)2006爱思唯尔有限公司保留所有权利。
Neogenin, a close relative of the axon guidance receptor Deleted in Colorectal Cancer (DCC), has been shown to be a receptor for members of the Netrin and Repulsive Guidance Molecule (RGM) families. While Netrin-l-Neogenin interactions result in a chernoattractive axon guidance response, the interaction between Neogenin and RGMa induces a chemorepulsive response. Evidence is now accumulating that Neogenin is a multi-functional receptor regulating many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Little is known of the function of Neogenin in the adult, however, a novel role in the regulation of iron homeostasis is now emerging. While the signal transduction pathways activated by Neogenin are poorly understood, it is clear that the functional outcome of Neogenin activation, at least in the embryo, depends on both the developmental context as well as the nature of the ligand. (c) 2006 Elsevier Ltd. All rights reserved.