[Cataplasma of traditional Chinese medicine].
[Cataplasma of traditional Chinese medicine].
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发表时间：
2003
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通讯作者：
W. Jia;Wen‐yuan Gao;Tao Wang;Yun-bin Liu;Jing Xue;P. Xiao
中科院分区：
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作者：
W. Jia;Wen‐yuan Gao;Tao Wang;Yun-bin Liu;Jing Xue;P. Xiao
变速器控制模块透皮贴剂（也称为“巴布剂”）是用于治疗疼痛的柔性粘合贴剂，所述疼痛由关节炎、扭伤和擦伤、肌腱阴道炎、腰椎突出、神经痛、骨质增生疼痛、腹部不适和转移性癌症等引起。自20世纪80年代以来，中国的研究者已经将这种现代的贴剂递送系统用于草药，并且获得了令人满意的结果，特别是用于治疗与骨疾病相关的各种类型的疼痛，腹部不适，90年代初，雷允上集团在上海率先建立了抗风湿药商业化生产线，成功地实现了中药巴布剂的规模化生产。到目前为止，市场上已经有许多中药巴布剂形式的产品，并且这些产品的临床研究表明，局部应用的草药制剂，特别是巴布剂形式的制剂，是患者治疗舒适性方面的优选制剂。与使用橡胶和松香作为粘合剂的传统制剂相比，巴布剂的优点在于草药提取物的亲脂性和亲水性成分被溶解，然后与有机聚合物“胶凝”，并且含有高达40%-70%水的药物基质充当“药物储存库”这将维持快速和持续释放的草药成分在几天内通过皮肤。虽然有传统的补救措施来减轻与骨骼疾病或癌症相关的疼痛和不适，但口服草药结合外用药物如中药巴布剂可显著减轻症状并改善其生活质量。本文从中药巴布剂的工艺发展、中药巴布剂的特点、中药巴布剂的发展现状及中药巴布剂技术的未来发展三个方面进行了综述。
The TCM (traditional Chinese medicine) transdermal plaster (also known as "cataplasma") are flexible adhesive patches used for treatment of pain, resulted from arthritis, sprain and bruise, tendovaginitis, lumbar spine protrude, neuralgia, hyperosteogeny ache, abdominal discomfort and metastatic cancer, etc. Since the 1980's, investigators in China have used this modern patch delivery system for herbal drugs and obtained satisfactory results especially from the treatment of various types of pain associated with bone diseases, abdominal discomfort, and tumors, etc. The production of TCM cataplasma was successfully scaled up in early 90's and the commercial product line for an antirheumatic agent was first established in Shanghai by Leiyunshang Group. Thus far, a number of products in the form of TCM cataplasma became commercially available in the market, and clinical investigations with these products indicated that topically applicable herbal preparations, especially in the form of cataplasma, are preferred formulations with respect to the treatment comfort of the patient. Compared to the traditional preparations which utilize rubber and rosin as adhesives, cataplasma is advantageous in that the lipophilic and hydrophilic ingredients of the herbal extracts are solubilized and then "gellified" with the organic polymers, and that the drug matrix containing up to 40%-70% of water serves as a "drug reservoir" that will sustain the quick and continuous release of herbal ingredients over several days across the skin. While there are conventional remedies for palliation of pain and discomfort associated with bone diseases or cancers, administration of oral medicinal herbs combined with topical agents such as TCM cataplasma may significantly alleviate the symptoms and improve their quality of life. This article provides a review on three aspects, which include the process development, characteristics and developmental status of TCM cataplasma, and future development of such a technology.