Precursors of essential hypertension. The role of body fat distribution pattern.
Precursors of essential hypertension. The role of body fat distribution pattern.
复制标题
原发性高血压的前兆。
DOI：
10.1093/oxfordjournals.aje.a115123
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发表时间：
1989
影响因子：
5
通讯作者：
QuesenberryJr,CP
中科院分区：
文献类型：
--
作者：
Selby,JV;Friedman,GD;QuesenberryJr,CP
Selby，J. V.（Kaiser Permanente（Medical Care Program，Oakland，CA 94611），G. D. Friedman和C. P. Quesenberry，Jr.原发性高血压的前兆：身体脂肪分布模式的作用。Am J Epidemlol 1989; 129：43- 53。从计算机多相健康检查记录和病历回顾中，记录了Kaiser Permanente医疗保健计划（北方加州地区）的1，031名成年成员在1964年至1972年期间从正常血压到55岁的原发性高血压的进展。每个病例在年龄、性别、种族、数量和多相性的日期上与持续血压正常的对照组相匹配。在609对基线测量肩胛下和三头肌皮褶的患者中，从基线到首次出现多相性高血压的平均时间间隔为5.7年，高血压发病的平均年龄为47岁。基线测量的体重指数、肩胛下皮褶厚度和三头肌皮褶厚度分别预测高血压的发生（比值比分别为3.85、3.75和2.29，最高和最低五分位数比较，p< 0.0001）。当两个皮褶都包含在同一模型中时，肩胛下皮褶具有高度预测性，三头肌皮褶不再与风险相关。当作者控制总体肥胖（体重指数）时，肩胛下皮褶厚度仍然具有高度预测性（p< 0.0001）。在330对同时进行高血压多相性皮褶测量的患者中，体重增加是高血压的强预测因子。肩胛下皮褶的增加仅在女性中赋予风险的小幅增加。作者得出结论，中心沉积的身体脂肪增加了患原发性高血压的风险，与肥胖的总体水平无关，而外周沉积的脂肪则没有。
Selby, J. V. (Kaiser Permanente (Medical Care Program, Oakland, CA 94611), G. D. Friedman, and C. P. Quesenberry, Jr. Precursors of essential hypertension: the role of body fat distribution pattern.Am J Epidemlol1989; 129:43–53.Progression from normotension between 1964 and 1972 to essential hypertension by age 55 years was documented in 1,031 adult members of the Kaiser Permanente Medical Care Program (Northern California region) from computerized multiphasic health checkup records and medical record review. Each case was matched to a persistently normotensive control on age, sex, race, number, and dates of muttiphasics. in 609 pairs with baseline measurements of subscapular and triceps skinfolds, mean interval from baseline to the case's first hypertensive multiphasic was 5.7 years, and mean age at onset of hypertension was 47 years. Baseline measures of body mass index, subscapular skinfold, and triceps skinfold were each predictive of development of hypertension (odds ratios 3.85, 3.75, and 2.29 respectively, comparing highest with lowest quinties,p< 0.0001 for each). When both sklnfolds were included in the same model, subscapular skinfold was highly predictive and triceps skinfold was no longer related to risk. When the authors controlled for overall obesity (body mass index), subscapular skinfold remained highly predictive (p< 0.0001). In 330 pairs who also had skinfold measurements at the hypertensive multiphasic, weight gain was a strong predictor of hypertension. Increase in subscapular skinfold conferred a small Increase in risk In women only. The authors conclude that centrally deposited body fat increases risk for developing essential hypertension Independent of the overall level of obesity, while peripherally deposited fat does not.