PSYCHIATRIC-DISORDER AND COGNITIVE IMPAIRMENT IN SYSTEMIC LUPUS-ERYTHEMATOSUS
PSYCHIATRIC-DISORDER AND COGNITIVE IMPAIRMENT IN SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1002/art.1780350409
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发表时间：
1992-04-01
影响因子：
--
通讯作者：
HOLT, PJL
中科院分区：
文献类型：
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作者：
HAY, EM;BLACK, D;HOLT, PJL
目标. 了解系统性红斑狼疮（SLE）患者精神障碍的时点患病率。 探讨精神障碍与社会压力、认知功能障碍、系统性疾病活动和皮质类固醇治疗之间的关系。 采用标准化精神病学和临床研究方法对73例连续SLE患者进行横断面研究。 15例患者（20.5%）目前存在精神障碍，与社会压力、缺乏社会支持和2项认知功能测试（言语流畅性测试和本顿视觉保持测试，A部分，错误数）的损害显著相关。 与全身疾病活动或皮质类固醇治疗无关。 在26%的患者中发现了2项或2项以上的认知功能障碍，并且与中枢神经系统（CNS）疾病的临床证据相关，但与全身疾病活动或皮质类固醇治疗无关。 精神障碍的点患病率在这个队列中的SLE患者被发现是类似的观察类风湿关节炎患者。 它与社会压力和2个认知障碍指标独立相关，但与全身疾病活动或皮质类固醇治疗无关。 显著的认知功能障碍存在于一个显着的百分比的患者，即使没有明显的证据表明中枢神经系统的参与。
Objectives. To determine the point prevalence of psychiatric disorder in patients with systemic lupus erythematosus (SLE). To investigate associations between psychiatric disorder and social stress, cognitive impairment, systemic disease activity, and corticosteroid therapy.Methods. A cross-sectional study of 73 consecutive patients with SLE assessed using standardized psychiatric and clinical research methods.Results. Current psychiatric disorder was present in 15 patients (20.5%) and was significantly associated with social stress, lack of social support, and impairment on 2 tests of cognitive function (Verbal Fluency Test and Benton Visual Retention Test, Part A, number of errors). There was no association with systemic disease activity or corticosteroid therapy. Cognitive impairment on 2 or more tests was found in 26% and was associated with clinical evidence of central nervous system (CNS) disease, but not systemic disease activity or corticosteroid therapy.Conclusions. The point prevalence of psychiatric disorder in this cohort of patients with SLE was found to be similar to that observed in patients with rheumatoid arthritis. It was independently associated with social stress and 2 indicators of cognitive impairment, but not with systemic disease activity or corticosteroid therapy. Marked cognitive impairment was present in a significant percentage of patients even when there was no overt evidence of CNS involvement.