Oxidation of Guanosine Monophosphate with O2 via a Ru-peroxo Complex in Water
Oxidation of Guanosine Monophosphate with O2 via a Ru-peroxo Complex in Water
复制标题
通过水中的钌-过氧配合物用 O2 氧化单磷酸鸟苷
DOI：
10.1002/asia.201801267
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Seiji
中科院分区：
文献类型：
--
作者：
Takenaka;Makoto; Kikkawa;Mitsuhiro; Matsumoto;Takahiro; Yatabe;Takeshi; Ando;Tatsuya; Yoon;Ki-Seok; Ogo;Seiji
活性氧（ROS）对DNA的氧化损伤是导致衰老和癌症的原因。虽然已经进行了许多关于ROS对DNA损伤的研究，但还没有关于水中金属基物种氧化RNA成分（如鸟苷一磷酸）的报道。在这里，我们报道了第一个由o2衍生的金属基氧结合物在水中将单磷酸鸟苷氧化为8 -氧基单磷酸鸟苷的案例。
Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal‐based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8‐oxoguanosine monophosphate by a metal‐based oxygen bound species, derived from O2and in water.