Systemic spread is an early step in breast cancer
Systemic spread is an early step in breast cancer
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DOI：
10.1016/j.ccr.2007.12.003
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发表时间：
2008-01-01
期刊：
影响因子：
50.3
通讯作者：
Klein, Christoph A.
中科院分区：
文献类型：
--
作者：
Huesemann, Yves;Geigl, Jochen B.;Klein, Christoph A.
转移是癌症进展中的晚期事件，这一点已被广泛接受。然而，在这里，我们发现肿瘤细胞可以从HER-2和PyMT转基因小鼠的最早上皮改变和女性导管原位癌中全身性传播。移植单个癌前HER-2转基因腺体的野生型小鼠在骨髓和肺中显示出播散的肿瘤细胞和微转移。在患者和小鼠模型中，小肿瘤和大肿瘤的播散性癌细胞数量及其核型异常相似。当通过骨髓移植激活到野生型受体中时，80个早期播散的癌细胞足以诱导致命的癌变。因此，早期播散的癌细胞从休眠状态中释放出来可能是异时转移的原因。
It is widely accepted that metastasis is a late event in cancer progression. Here, however, we show that tumor cells can disseminate systemically from earliest epithelial alterations in HER-2 and PyMT transgenic mice and from ductal carcinoma in situ in women. Wild-type mice transplanted with single premalignant HER-2 transgenic glands displayed disseminated tumor cells and micrometastasis in bone marrow and lungs. The number of disseminated cancer cells and their karyotypic abnormalities were similar for small and large tumors in patients and mouse models. When activated by bone marrow transplantation into wild-type recipients, 80 early-disseminated cancer cells sufficed to induce lethal carcinosis. Therefore, release from dormancy of early-disseminated cancer cells may frequently account for metachronous metastasis.