Human herpesvirus 8 infection occurs following adolescence in the United States
Human herpesvirus 8 infection occurs following adolescence in the United States
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DOI：
10.1086/517298
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发表时间：
1997-09-01
影响因子：
6.4
通讯作者：
Jeang, KT
中科院分区：
文献类型：
--
作者：
Blauvelt, A;Sei, S;Jeang, KT
最近的证据表明，人类疱疹病毒8型（HHV-8）感染仅限于卡波西肉瘤（KS）患者或随后可能发展为KS的患者。为了准确地确定感染在美国的流行程度，对患有艾滋病的儿童和成人进行了HHV-8感染的检查，以确定HHV-8（像其他疱疹病毒一样）是否容易在免疫抑制的人群中检测到。采用巢式聚合酶链反应，在51例儿童血液白细胞中分别检测到HHV-8、eb病毒和巨细胞病毒特异性DNA，分别为0例、26例（51%）和9例（18%）。同样，在儿童血清分析中未检测到hhv -8特异性抗体。相比之下，33例无KS的成年艾滋病患者中有9例（27%）检测到HHV-8 DNA。这些发现表明，HHV-8在美国的传播模式不同于其他疱疹病毒，因为原发性感染主要发生在成年人中。
Most recent evidence suggests that human herpesvirus 8 (HHV-8) infection is restricted to persons with Kaposi's sarcoma (KS) or to persons who may subsequently develop KS. To accurately determine the prevalence of infection in the United States, children and adults with AIDS were examined for evidence of HHV-8 infection to see whether HHV-8 (like other herpesviruses) would be readily detected in immunosuppressed persons. By use of nested polymerase chain reaction, DNA specific for HHV-8, Epstein-Barr virus, and cytomegalovirus was detected in blood leukocytes from 0, 26 (51%), and 9 (18%), respectively, of 51 children. Similarly, HHV-8-specific antibodies were not detected in analyses of sera from the children. By contrast, HHV-8 DNA was detected in 9 (27%) of 33 adult AIDS patients without KS. These findings suggest that the pattern of transmission of HHV-8 in the United States differs from that of other herpesviruses in that primary infection occurs predominantly in adults.