Immunoglobulin γ marker genes as effect modifiers of Epstein-Barr virus-multiple sclerosis association.
Immunoglobulin γ marker genes as effect modifiers of Epstein-Barr virus-multiple sclerosis association.
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免疫球蛋白γ标记基因作为 Epstein-Barr 病毒-多发性硬化症关联的效应调节剂。
DOI：
10.1111/imm.13625
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发表时间：
2023
期刊：
影响因子：
6.4
通讯作者：
Pandey,JanardanP
中科院分区：
文献类型：
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作者：
Pandey,JanardanP
几十年来，人们一直怀疑eb病毒（EBV）参与多发性硬化症（MS）的发病机制。最近，一项大型（1000万受试者）流行病学研究报告称，EBV血清阳性患者发生多发性硬化症的风险是血清阴性患者的32倍，这有力地支持了EBV可能是这种自身免疫性疾病发展的一个原因的观点。如此常见的病毒怎么会导致一种相对罕见的疾病呢？答案可能在于某些基因分布的个体间差异，这些基因同时使个体易患多发性硬化症，并影响对EBV的免疫力。由免疫球蛋白γ重链（IGHG）基因编码的GM （γ标记物）等位型与MS和EBV的免疫生物学有关，因此是EBV-MS关联的理想候选介质。
Involvement of Epstein–Barr virus (EBV) in the etiopathogenesis of multiple sclerosis (MS) has been suspected for decades. Recently, a large (10 million subjects) epidemiological study—which reported a 32-fold increased risk of MS in EBV seropositive compared to seronegative individuals—has significantly bolstered the argument that EBV may be a causal factor in the development of this autoimmune disease [1]. How could such a common virus cause a relatively rare disease? The answer may lie in the interindividual differences in the distribution of certain genes which simultaneously predispose an individual to the development of MS and also influence immunity to EBV. GM (γ marker) allotypes, encoded by immunoglobulin γ heavy chain (IGHG) genes, have been implicated in the immunobiology of both MS and EBV, and thus are ideal candidates to act as mediators of the observed EBV-MS association.