Perinatal risk factors for early onset of Type 1 diabetes in a 2000-2005 birth cohort
Perinatal risk factors for early onset of Type 1 diabetes in a 2000-2005 birth cohort
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DOI：
10.1111/j.1464-5491.2009.02878.x
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发表时间：
2009-12-01
影响因子：
3.5
通讯作者：
Roberts, C. L.
中科院分区：
文献类型：
--
作者：
Algert, C. S.;McElduff, A.;Roberts, C. L.
目的 在 2000-2005 年澳大利亚出生队列中检查 6 岁之前发生 1 型糖尿病的围产期危险因素。方法分析了纵向关联的分娩和入院记录（截至 2007 年 6 月）的数据。根据医院记录中的国际疾病分类10个诊断代码来识别母亲和儿童的糖尿病。结果在502 040名活产儿中，有272名儿童因首次诊断为糖尿病而入院。 2000 年出生的婴儿的发病率为每 10 万人年 16.0 例。母亲 1 型糖尿病是一个显着的危险因素 [粗相对风险 (RR) 6.33]，但母亲 2 型糖尿病和妊娠糖尿病与孩子的糖尿病没有显着相关性。晚期早产（34-36周）（RR 1.64）和剖腹产（RR 1.30）会增加糖尿病入院的风险。胎龄大小与糖尿病发病显着相关（胎龄较小RR 0.48），但出生体重类别和作为连续变量的出生体重均与糖尿病风险无关。母亲年龄的增加与孩子患糖尿病的风险增加相关（每增加 5 岁，RR 为 1.13）。 结论 这项研究在最近的出生队列中确定了与 6 岁之前发生 1 型糖尿病相关的危险因素。胎龄大小与早发 1 型糖尿病的风险存在一致的相关性，较小的体型具有保护作用。在评估糖尿病风险时，应优先考虑胎龄尺寸测量，而不是出生体重阈值。
AimsTo examine perinatal risk factors for the onset of Type 1 diabetes before 6 years of age, in a 2000-2005 Australian birth cohort.MethodsData from longitudinally linked delivery and hospital admission records (until June 2007) were analysed. Diabetes in mothers and children was identified from International Classification of Diseases 10 diagnosis codes in the hospital records.ResultsThere were 272 children admitted to hospital with a first diagnosis of diabetes out of 502 040 live births. Incidence for the infants born in 2000 was 16.0 per 100 000 person-years. Maternal Type 1 diabetes was a significant risk factor [crude relative risk (RR) 6.33], but maternal Type 2 diabetes and gestational diabetes were not significantly associated with diabetes in the child. Late preterm birth (34-36 weeks) (RR 1.64) and caesarean section (RR 1.30) increased the risk of a diabetes admission. Size-for-gestational-age was significantly associated with onset of diabetes (small-for-gestational age RR 0.48), but neither birth weight categories nor birth weight as a continuous variable were associated with risk of diabetes. Increasing maternal age was associated with an increased risk of diabetes in the child (RR 1.13 for each additional 5 years of age).ConclusionsThis study identified risk factors associated with onset of Type 1 diabetes before 6 years of age, in a recent birth cohort. Size-for-gestational-age had a consistent association with risk of early onset of Type 1 diabetes, small size being protective. Size-for-gestational-age measures should be preferred to birth weight thresholds when assessing risk of diabetes.