DETERMINANTS OF MORTALITY AND MULTIORGAN DYSFUNCTION IN CARDIAC-SURGERY PATIENTS REQUIRING PROLONGED MECHANICAL VENTILATION
DETERMINANTS OF MORTALITY AND MULTIORGAN DYSFUNCTION IN CARDIAC-SURGERY PATIENTS REQUIRING PROLONGED MECHANICAL VENTILATION
复制标题
DOI：
10.1378/chest.107.5.1395
复制
发表时间：
1995-05-01
期刊：
影响因子：
9.6
通讯作者：
PASQUE, C
中科院分区：
文献类型：
--
作者：
KOLLEF, MH;WRAGGE, T;PASQUE, C
目的：目的：研究心脏手术后需要长时间机械通气（即>48 h）的患者的死亡率和多器官功能障碍的发生特点。设计：一项前瞻性队列研究。背景：圣路易斯巴恩斯医院，一个学术性三级护理中心。患者或其他参与者：共有107名连续患者接受心脏手术并需要长时间机械通气，干预措施：前瞻性患者监测和数据收集。主要结局指标：ICU死亡率和多器官功能障碍。结果：在472例连续入院的心脏外科ICU手术后，107（22.7%）需要长期机械通气。其中21例（19.6%）患者在住院期间死亡。在逻辑回归分析中，器官系统衰竭指数（OSFI）≥ 3是与ICU死亡率独立相关的唯一特征（p
Objectives: To identify characteristics associated with mortality and the development of multiorgan dysfunction in patients who had undergone cardiac surgery and required prolonged mechanical ventilation, ie, >48 h.Design: A prospective cohort study.Setting: Barnes Hospital, St. Louis, an academic tertiary care center.Patients or other participants: A total of 107 consecutive patients undergoing cardiac surgery and requiring prolonged mechanical ventilation,Interventions: Prospective patient surveillance and data collection.Main outcome measures: ICU mortality and multiorgan dysfunction.Results: Among 472 consecutive patients admitted to the cardiac surgery ICU following surgery, 107 (22.7%) required prolonged mechanical ventilation. Twenty-one of these patients (19.6%) died during their hospitalization. In a logistic-regression analysis, the development of an organ system failure index (OSFI) of 3 or greater was the only characteristic independently associated with ICU mortality (p