In vivo gated 4D imaging of the embryonic heart using optical coherence tomography
In vivo gated 4D imaging of the embryonic heart using optical coherence tomography
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DOI：
10.1117/1.2747208
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发表时间：
2007-05-01
影响因子：
3.5
通讯作者：
Rollins, Andrew M.
中科院分区：
文献类型：
--
作者：
Jenkins, Michael W.;Chughtai, Osman Q.;Rollins, Andrew M.
我们通过光学相干断层扫描（OCT）首次展示了鸟类胚胎心脏的体内门控4D图像。我们展示了一个在体内跳动的鹌鹑心脏的门控4D数据集，由类似于多次心跳积累的864,000次a扫描组成。从外围卵黄血管采集的激光多普勒测速（LDV）信号产生门控触发，使我们能够将图像采集与心脏周期相结合。为了充分表征心脏缺陷的发生和机制，需要一种能够在早期发育阶段同时评估结构和功能的工具，门控OCT有能力成为这样的工具。(C) 2007光学仪器工程师学会。
We demonstrate the first in vivo gated 4D images of avian embryonic hearts by use of optical coherence tomography (OCT). We present a gated 4D dataset of an in vivo beating quail heart consisting of similar to 864,000 A-scans accumulated over multiple heartbeats. Generation of a gating trigger from a laser Doppler velocimetry (LDV) signal, collected from an outlying vitelline vessel, enabled us to gate image acquisition to the cardiac cycle. To fully characterize the genesis and mechanisms of cardiac defects, a tool capable of assessing structure and function simultaneously at early stages of development is needed, and gated OCT has the capability to become such a tool. (C) 2007 society of Photo-Optical Instrumentation Engineers.