The role of Klebsiella in Crohn's disease with a potential for the use of antimicrobial measures.
The role of Klebsiella in Crohn's disease with a potential for the use of antimicrobial measures.
复制标题
克雷伯菌在克罗恩病中的作用具有使用抗菌措施的潜力。
DOI：
10.1155/2013/610393
复制
发表时间：
2013
影响因子：
2.3
通讯作者：
Wilson C
中科院分区：
文献类型：
--
作者：
Rashid T;Ebringer A;Wilson C
有一个普遍的共识，克罗恩病（CD）的发展是由于免疫介导的组织损伤引发的感染肠道微生物剂。根据现有的微生物学、分子学和免疫学研究结果，克雷伯氏菌属微生物似乎在CD患者肠道和关节组织病理损伤的发生和持续中起关键作用。英国六个不同的胃肠病学中心报告了CD患者中克雷伯氏菌抗体水平升高。高摄入含淀粉饮食、肠道微生物生长增强和克雷伯氏菌产生普鲁兰酶之间存在关系。建议通过使用抗生素和低淀粉饮食根除这些微生物，除了目前使用的治疗外，还可以帮助缓解或阻止CD的疾病过程。
There is a general consensus that Crohn's disease (CD) develops as the result of immune-mediated tissue damage triggered by infections with intestinal microbial agents. Based on the results of existing microbiological, molecular, and immunological studies, Klebsiella microbe seems to have a key role in the initiation and perpetuation of the pathological damage involving the gut and joint tissues in patients with CD. Six different gastroenterology centres in the UK have reported elevated levels of antibodies to Klebsiella in CD patients. There is a relationship between high intake of starch-containing diet, enhanced growth of gut microbes, and the production of pullulanases by Klebsiella. It is proposed that eradication of these microbes by the use of antibiotics and low starch diet, in addition to the currently used treatment, could help in alleviating or halting the disease process in CD.