Osteopenia and osteoporosis in patients with HIV: a review of current concepts.
Osteopenia and osteoporosis in patients with HIV: a review of current concepts.
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DOI：
10.1007/s11908-006-0012-x
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发表时间：
2006-03-01
影响因子：
3.1
通讯作者：
McComsey, Grace A
中科院分区：
文献类型：
--
作者：
Brown, Todd T;McComsey, Grace A
自从联合疗法中有效的抗逆转录病毒疗法出现以来，多项流行病学研究表明，骨质减少和骨质疏松症在 HIV 感染患者中很常见。然而，这种潜在并发症仍然存在许多不确定性，这可能会让艾滋病毒临床医生感到困惑。本综述总结了 HIV 患者骨矿物质密度下降的流行病学、病理生理学、建议的筛查策略和治疗方案。我们的目标是审查现有数据，突出有争议的问题，并为无法获得支持数据的临床医生提供指导。
Since the advent of potent antiretroviral therapy in combination regimens, multiple epidemiologic studies have shown that osteopenia and osteoporosis are common among patients with HIV infection. However, there remain many areas of uncertainty about this potential complication, which can be confusing for the HIV clinician. This review summarizes the epidemiology, pathophysiology, suggested screening strategies, and management options of decreased bone mineral density in patients with HIV. Our aims are to review the available data, highlight controversial issues, and provide guidance for clinicians where supporting data are unavailable.