Dissociation of systemic and central effects of neurotensin on the secretion of growth hormone, prolactin, and thyrotropin.
Dissociation of systemic and central effects of neurotensin on the secretion of growth hormone, prolactin, and thyrotropin.
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神经降压素对生长激素、催乳素和促甲状腺素分泌的全身和中枢作用的分离。
DOI：
10.1210/endo-103-5-1903
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发表时间：
1978
期刊：
影响因子：
4.8
通讯作者：
L. A. Frohman
中科院分区：
文献类型：
--
作者：
Kiyoshi Maeda;L. A. Frohman
神经降压素 (NT) 是一种最初从下丘脑中分离出来的十三肽，具有多种生物效应，具体取决于肽的给药部位。在乌拉坦麻醉、雌激素引发的雄性大鼠中比较 NT 对 GH、PRL 和 TSH 分泌的全身和中枢影响。静脉注射 NT（30 /xg/kg 或 7.5-9.0 /xg/大鼠）导致血浆 GH 和 PRL 显着升高，在 5 分钟时达到峰值，血浆 TSH 显着升高，在 15 分钟时达到峰值。相比之下，心室内 (ivt) NT（2 和 5 /ig）显着降低了所有三种激素的血浆水平。静脉注射NT（0.2和2.0壶）抑制全身TRH（0.4/ig/kg）后PRL和TSH升高。 NT（0.5 和 0.2 壶，静脉注射）完全抑制了氯丙嗪（200 壶/公斤，静脉注射）后 GH 的升高，而 PRL 的升高则被部分抑制。为了评估 P 物质、生长抑素和组胺对 NT 效应的可能介导，测量了垂体激素对这些化合物的反应。注射...
Neurotensin (NT), a tridecapeptide originally isolated from the hypothalamus, exhibits a wide variety of biological effects which depend on the site of peptide administration. The systemic and central effects of NT on GH, PRL, and TSH secretion were compared in urethane anesthetized, estrogen-primed male rats.ntravenous NT (30 /xg/kg or 7.5–9.0 /xg/rat) produced a marked rise in plasma GH and PRL, which peaked at 5 rnin, and in plasma TSH, which peaked at 15 min. In contrast, intraventricular (ivt) NT (2 and 5 /ig) significantly decreased plasma levels of all three hormones. The PRL and TSH rises after systemic TRH (0.4 /ig/ kg) were inhibited by the ivt injection of NT (0.2 and 2.0 jug). The GH rise after chlorpromazine (200 jug/kg, iv) was completely suppressed by NT (0.5 and 0.2 jug, ivt), whereas that of PRL was partially suppressed. To evaluate the possible mediation of NT effects by substance P, somatostatin, and histamine, the pituitary hormon responses to these compounds were measured. The injecti...